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Polymerized silicone elastomer dispersed in polyvinylpyrrolidone (Bioplastique) reactions show granulomas with irregularly shaped cystic spaces containing translucent treatment of chlamydia purchase primaquine 15mg otc, jagged 9 medications that can cause heartburn discount 15 mg primaquine, popcorn-like medicine 657 buy primaquine 15 mg otc, non-birefringent particles of varying size dispersed in a sclerotic stroma surrounded by abundant multinucleated foreign body giant cells medication 3 checks primaquine 15mg line, some of them containing asteroid bodies. Human histology and persistence of various injectable filler substances for soft tissue augmentation. Adverse cutaneous reactions to soft tissue fillers-a review of the histological features. The tumor cells exhibit increased cytoplasm and nuclear grooves with smooth chromatin and associated eosinophilic inflammation. The characteristic granular cytoplasm of the tumor cells and overlying pseudoepitheliomatous hyperplasia are not evident. The tumor cells do not exhibit the classic nested morphology of a melanocytic nevus and lacks features of maturation, pigment. The lesions lacks features of immature vascular formation with red blood cell extravasation at the periphery or an infiltrative pattern of growth by the tumor cells. Question 98 the special stain likely to be most helpful in confirming the diagnosis is: A. Since the cells are positive for S100, this lesion is unlikely to represent a mycobacterial infection. Given the negativity for numerous other melanocytic markers, an additional melanocytic marker is unlikely to be of high yield. Together with the morphology and the immunophenotypic findings already reported, this would confirm the diagnosis of Langerhans Cell Histiocytosis. Langerhans cells contain increased pale eosinophilic cytoplasm with enlarged, folded or grooved nuclei (often “kidney shaped”) with smooth chromatin and lacking conspicuous nucleoli. Prominent Langerhans cell migration in the arthropod bite reactions, simulating Langerhans cell histiocytosis. Myeloid leukemia cutis (Incorrect) the immunophenotype seen here is B-cell, not myeloid. Mantle cell lymphoma (Correct) the morphologic features and the immunophenotype seen here are consistent with mantle cell lymphoma. Clinical Features Mantle cell lymphoma is a B-cell lymphoma generally composed of monomorphic small to medium-sized lymphocytes with irregular nuclear contours and expressing Cyclin D1. Other frequent sites are the spleen, gastrointestinal tract, and bone marrow (with or without peripheral blood involvement). Cutaneous lesions are uncommon but may represent the first manifestation of mantle cell lymphoma. Neoplastic large/transformed cells resembling centroblasts, immunoblasts or paraimmunoblasts are not seen. There is a spectrum of morphologic variants, including small cell (small round lymphocytes mimicking small lymphocytic lymphoma), blastoid (cells resembling lymphoblasts with dispersed chromatin and high mitotic rate) and pleomorphic (larger pleomorphic cells with oval to irregular nuclear contours and often prominent nucleoli). Mantle cell lymphoma involving skin: cutaneous lesions may be the first manifestation of disease and tumors often have blastoid cytologic features. The vast majority of the plasma cells are immunoreactive with lambda immunoglobulin light chain stain. A systemic work-up (including bone marrow examination, imaging studies, and serum/urine protein electrophoresis) is negative. Secondary syphilis (Incorrect) While syphilis is often associated with plasma cell-rich infiltrates, the plasma cells should be polytypic. Secondary cutaneous involvement by plasma cell myeloma (Incorrect) the presence of an atypical plasma cell-rich infiltrate with light chain restriction would raise the possibility of a plasma cell dyscrasia. However, the diagnosis of plasma cell myeloma requires additional clinical and pathologic findings, which are not present in this case. Monoclonal gammopathy of undetermined significance (Incorrect) A monoclonal gammopathy is not present in this case. Cutaneous plasmacytosis (Incorrect) While cutaneous plasmacytosis shows a plasma cell rich dermal infiltrate, the plasma cells should be polytypic. Cutaneous marginal zone B-cell lymphoma (Correct) the clinical and histopathologic findings are consistent with cutaneous marginal zone B-cell lymphoma. This diagnostic category currently includes cases previously labeled primary cutaneous plasmacytoma without underlying plasma cell myeloma (extramedullary plasmacytoma of the skin). Lytic bone lesions (Incorrect) this is not a feature of cutaneous marginal zone B-cell lymphoma. Amyloidosis (Incorrect) Amyloidosis is not commonly seen in the setting of cutaneous marginal zone B-cell lymphoma. Renal insufficiency (Incorrect) this may be seen in patients with plasma cell myeloma but is not a feature of cutaneous marginal zone B-cell lymphoma. Patients generally present with red to violaceous papules, plaques and/or nodules on the trunk and/or extremities. Cutaneous recurrences are common, but dissemination to extracutaneous sites or large cell transformation is rare. If frequent plasma cells are present in a dense dermal infiltrate with lymphoid follicles, consider the possibility of cutaneous marginal zone lymphoma with reactive follicles. Kappa and lambda immunoglobulin light chain stains are usually helpful in this differential. Dermatomyositis (Incorrect) the features of dermatomyositis show mild vacuolar changes with scattered cytoid bodies and a sparse superficial perivascular infiltrate of lymphocytes. Lichen planus (Incorrect) Lichen planus has epidermal acanthosis, hypergranulosis, interface changes with “saw toothing” and cytoid body formation. Lichenoid drug eruption (Incorrect) Similar findings to lichen planus, often with a perivascular infiltrate. Pityriasis rosea (Incorrect) Given the interface and non-spongiotic features of the inflammatory infiltrate, this diagnosis is not correct. Secondary syphilis (Correct) Given the interface and non-spongiotic features of the inflammatory infiltrate, this diagnosis is not correct. Anti-spirochete immunohistochemical study (Correct) this stain will identify the thin, delicate 4-15 micron long spiral organisms in the intercellular spaces, as well as in macrophages, around blood vessels, endothelial cells and even plasma cells. Direct immunofluorescence study (Incorrect) this study is non-diagnostic in secondary syphilis. Interface inflammation is typical and as such, several other diagnoses in the lichenoid or interface category can be considered. Recognizing the interface dermatitis and plasma cells within the infiltrate make this the correct diagnosis. Lichen planus may have similar changes but most often has epidermal acanthosis, hypergranulosis, interface changes with “saw toothing” and cytoid body formation. Anti-spirochete immunohistochemical stains are now available and will identify the thin, delicate 4-15 micron long spiral organisms in the intercellular spaces, as well as in macrophages, around blood vessels, endothelial cells and even plasma cells. Dermatomyositis (Incorrect) Although mild to focal interface changes can be seen, the characteristic eosinophilic globules seen in the papillary dermis seen in this biopsy are not noted in dermatomyositis. Chronic and lichenified dermatitis (Incorrect) Irregular epidermal acanthosis with some compressed collagen and scattered dermal melanophages in the papillary dermis can be seen in a chronic dermatitis. The characteristic eosinophilic globules seen in this biopsy are not noted in a chronic and lichenified dermatitis. Lichen amyloidosis (Correct) Focal interface changes with characteristic small eosinophilic globular deposits seen in the papillary dermis often with scattered dermal melanophages correctly identify this as lichen amyloidosis. Lichenoid drug eruption (Incorrect) Similar findings to lichen planus consisting of a band like lymphocytic infiltrate with interface changes. Plasma cells and eosinophils can be seen in the infiltrate which can also be perivascular. Systemic amyloidosis with cutaneous involvement (Incorrect) Systemic amyloidosis with cutaneous involvement typically demonstrates pale eosinophilic deposition throughout the dermis but frequently around blood vessels. Crystal violet (Correct) Multiple stains are positive in amyloidosis including crystal violet, Congo red, Thioflavin T, cotton dyes (Pagoda Red) and acid-orcein Giemsa. Discussion Focal interface changes with characteristic small eosinophilic globular deposits seen in the papillary dermis often with scattered dermal melanophages correctly identify this as lichen amyloidosis. Irregular epidermal acanthosis with some compressed collagen and scattered dermal melanophages in the papillary dermis can also be seen in chronic dermatitis but the characteristic eosinophilic globules seen in this biopsy are not noted in a chronic and lichenified dermatitis.

Clinical Features: Porokeratosis is a disorder of keratinization treatment of uti order primaquine 15mg online, characterized clinically by hyperkeratotic papules or plaques with a thread-like elevated border medicine - generic 15mg primaquine. Common clinical variants include: classic porokeratosis of Mibelli treatment atrial fibrillation 15mg primaquine with visa, disseminated superficial porokeratosis symptoms 0f brain tumor order genuine primaquine online, porokeratosis palmaris et plantaris disseminata, linear porokeratosis and punctate porokeratosis. The authors used the Greek words ptyche (fold) and trope (a turning) to depict the flexural distribution of this condition. Histopathologic Features: the typical diagnostic histopathologic feature of porokeratosis is the cornoid lamellae. The cornoid lamella is a thin column of parakeratotic cells with absent or decreased underlying granular zone and vacuolated or dyskeratotic cells in the spinous layer. An unusual case of porokeratosis involving the natal cleft: porokeratosis ptychotropica Cutaneous plasmacytoma (Incorrect) Primary and secondary forms of cutaneous plasmacytoma are circumscribed, non-encapsulated infiltrates of plasma cells within the reticular dermis. The plasma cells show variable maturation with some binucleate forms and occasional mitoses. Eruptive xanthoma (Incorrect) the cellular infiltrate depends upon the age of the lesion in eruptive xanthoma. Neutrophils and lymphocytes generally accompany small histiocytes in early lesions. The histiocytes may include a variety of forms, often with a component of xanthomatized (foamy) and Touton multinucleate cells. Langerhans cell histiocytosis (Incorrect) Tumor cells in Langerhans cell histiocytosis are smaller than those present in this case and have reniform (coffee bean) vesicular nucleus with inconspicuous nucleolus and moderately abundant, light eosinophilic cytoplasm. There is a variable admixture of inflammatory cells, often with numerous eosinophils. Rosai-Dorfman disease (Correct) Characteristic histologic features include sheets of very large histiocytes with abundant feathery cytoplasm, few multinucleate cells, numerous plasma cells, and nodular aggregates of lymphocytes. Birbeck granules (Incorrect) these granules are cytoplasmic organelles that characterize Langerhans cells. Epidermotropism (Incorrect) Spread of cells into the epidermis from a dermal or subcutaneous pathology. Extracellular lipid (Incorrect) Extracellular lipid is a finding in some types of xanthoma, including eruptive xanthoma. Small numbers of xanthomatous histiocytes may be present in Rosai-Dorfman disease but there is no extracellular lipid deposition. Monoclonal population of plasma cells (Incorrect) the majority of cutaneous plasmacytomas are monoclonal. Although there is a prominent plasma cell component in Rosai-Dorfman disease, the plasma cells are polyclonal. Also referred to as sinus histiocytosis with massive lymphadenopathy, it commonly involves the lymph nodes with secondary skin involvement. These cases present with prominent bilateral cervical lymphadenopathy accompanied by fever, malaise, night sweats, and weight loss. Skin lesions may be solitary or multiple and may present as papules or nodules that are dermal or subcutaneous. Purely cutaneous disease is not associated with systemic symptoms and does not evolve to systemic disease even with long term follow-up. The clinical course is variable, with most lesions resolving spontaneously over weeks to months. Cutaneous Rosai-Dorfman disease: a clinical and histopathological study of 25 cases in China. Histologic features of cutaneous sinus histiocytosis (Rosai-Dorfman disease): study of cases both with and without systemic involvement. Effect of host, tumor, diagnostic, and treatment variables on outcomes in a large cohort with Merkel cell carcinoma. Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomas. Tumor infiltrating immune cells and outcome of Merkel cell carcinoma: a population-based study. Antibodies to Merkel cell polyomavirus T antigen oncoproteins reflect tumor burden in merkel cell carcinoma patients. T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus. Lymphoblastic B-cell lymphoma (Incorrect) Characterized by a monotonous, diffuse or nodular dermal infiltrate separated from the epidermis by a grenz zone. The cells have little cytoplasm and round to oval nuclei with finely disperse chromatin and inconspicuous nucleoli. Tumor cells dissect collagen bundles, as in this case, but perineural invasion is not a usual feature. Malignant melanoma, small cell variant (Correct) the neoplasm is composed of relatively monotonous small cells with scant cytoplasm and hyperchromatic nuclei. There is a vague nested pattern superficially with a subtle intraepidermal component. Merkel cell carcinoma (Incorrect) Merkel cell carcinoma can have a variety of histologic patterns. It most commonly presents as nodules or diffuse sheets of basophilic cells with granular (“salt and pepper”) chromatin pattern. The tumor cells dissect the collagen bundles, as in this case, and lymphovascular invasion is often present. Metastatic small cell carcinoma (Incorrect) Characterized by sheets, ribbons, or rosettes of small to medium-sized round-oval cells with minimal cytoplasm, salt and pepper chromatin, indistinct nucleoli, nuclear molding, smudging, and frequent mitotic figures. Peripheral primitive neuroectodermal tumor (Incorrect) Like this case, peripheral primitive neuroectodermal tumor is composed of relatively uniform small cells with round nuclei, finely distributed chromatin, and minimal cytoplasm. The tumors have a lobular or trabecular growth pattern with highly vascular stroma. Dendritic cell neurofibroma with pseudorosettes (Correct) the neoplasm forms nodules within the dermis that are composed of two cell types. Type I cells are small, dark cells with slightly irregular nucleus and scant cytoplasm. Neuroblastoma-like neurilemmoma (Incorrect) Neuroblastoma-like neurilemmoma is characterized by a proliferation of cells with round to oval nuclei, indistinct nucleoli, and scant cytoplasm. Lesional cells tend to form rosette-like structures around blood vessels or collagenous cores. Palisaded encapsulated neuroma (Incorrect) Palisaded encapsulated neuroma consists of a well circumscribed dermal nodule with incomplete encapsulation. It is composed of pale staining spindle cells arranged in short fascicles separated by artifactual clefting. The nuclei may be arranged in a palisaded fashion but pseudorosette formation is not present. Plexiform neurofibroma (Incorrect) Plexiform neurofibroma nodules consist of distended nerve portions that are much larger than the nodules in this case. Plexiform schwannoma (Incorrect) Plexiform schwannoma consists of multiple nodules within the dermis, as in this case. However, the nodules are generally composed of Antoni A type tissue with spindle-shaped Schwann cells arranged in interlacing fascicles. Question Which of the following histopathologic features characterizes this lesion Homer-Wright rosettes (Incorrect) Homer–Wright rosettes, seen most often in neuroblastomas or peripheral neuroepitheliomas, contain a central solid core of neurofibrillary material. Presence of intralesional axons (Incorrect) Lesional axons are seen in palisaded encapsulated neuroma C. Wagner-Meissner bodies (Incorrect) Wagner-Meissner bodies are seen in neurofibromas and schwannomas. Of the original series of 18 patients, none was associated with neurofibromatosis. Dendritic cell neurofibroma appears to be benign and cases have not shown evidence of recurrence, malignant transformation, or metastasis. A report of 18 cases of a distinct and hitherto unrecognized neurofibroma variant. Dendritic cell neurofibroma with pseudorosettes: two tumors in a patient with evidence of neurofibromatosis.

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Preemptive plasmaphere adsorption in patients with idiopathic dilated cardiomyopathy symptoms 5 dpo buy primaquine 15mg on line. Circulating factor associated with increased thy: results from protein A immunoadsorption medicine zantac effective primaquine 15mg. Am Heart J glomerular permeability to 5ht3 medications discount primaquine online american express albumin in recurrent focal segmen 2005;150:729–736 treatment quadriceps pain order 15mg primaquine amex. Staudt A, Staudt Y, Dorr M, Bohm M, Knebel F, Hummel A, tal glomerulosclerosis in adults. J Am Coll Algarra G, Pereira P, Rivera M, Suner M, Cabello V, Toro J, Cardiol 2004;44:829–836. Transplant Proc exchange for removal of antibeta1-adrenergic receptor anti 2006;38:1904–1905. Pardon A, Audard V, Caillard S, Moulin B, Desvaux D, Ben Cardiol 2009;30:374–376. Risk factors and outcome of focal and segmental glo to reduce anti-beta1-adrenergic receptor antibody in a patient merulosclerosis recurrence in adult renal transplant recipients. Inflammation a potential target for therapeutic mental glomerular sclerosis in renal transplant recipients: pre intervention in heart failure. Methodist Debakey Cardiovasc J dicting early disease recurrence may prolong allograft function. Efficacy of different berger A, Hoecker P, Mitterbauer M, Rabitsch W, Schulenburg low-density lipoprotein apheresis methods. Update on extracorporeal photochemotherapy mary and recurrent focal segmental glomerular sclerosis: a for graft-versus-host disease treatment. Extracorporeal photopheresis therapy in the man Cesaro S, Pillon M, Perotti C, Del Fante C, Faraci M, Riva agement of steroid-refractory or steroid-dependent cutaneous bella L, Calore E, De Stefano P, Zecca M, Giorgiani G, Bru chronic graft-versus-host disease after allogeneic stem cell giolo A, Balduzzi A, Dini G, Zanesco L, Dall’Amico R. Bone Marrow Trans Extracorporeal photochemotherapy for paediatric patients with plant 2003;31:459–465. Muncunill J, Vaquer P, Galmes A, Obrador A, Parera M, Bar analysis of predictors of response. Hereditary hemochromatosis—a new look at an Blood Marrow Transplant 2006;12 (1 Suppl 2):37–40. Brissot P, Guyader D, Loreal O, Laine F, Guillygomarc’h A, des B, Smith V, Khouri I, Giralt S, de Lima M, Hsu Y, Ghosh Moirand R, Deugnier Y. S, Neumann J, Andersson B, Qazilbash M, Hymes S, Kim S, Transfus Sci 2000;23:193–200. Calore E, Calo A, Tridello G, Cesaro S, Pillon M, Varotto S, Genet 1996;13:399–408. Bone Marrow phlebotomy and erythrocytapheresis of iron overload in Transplant 2008;42:609–617. Therapeutic the treatment of chronic graft-versus-host disease: trend for a erythrocytapheresis versus phlebotomy in the initial treatment possible cell dose-related effect Kanold J, Merlin E, Halle P, Paillard C, Marabelle A, Rapatel Transfus Apher Sci 2009;40:135–136. The United States National Prospective ric graft-versus-host disease after allogeneic marrow transplan Hemolytic Uremic Syndrome Study: microbiologic, serologic, tation: clinical practice guidelines based on field experience clinical, and epidemiologic findings. Prospective study of associated syndromes: review of outcome data derived from extracorporeal photopheresis in steroid-refractory or steroid-re clinical trials and open studies. Apisarnthanarax N, Donato M, Korbling M, Couriel D, Gajew Ferrara J, Soiffer R, Giralt S. Biol Blood Marrow Transplant 2005;11:571– mic syndrome responsive to steroids and intravenous immune 575. Philadelphia: syndrome caused by factor H mutation: is single kidney trans Mosby Elsevier. Besbas N, Karpman D, Landau D, Loirat C, Proesmans W, diarrhea-negative hemolytic uremic syndrome. Leukapheresis reduces early mortality in patients with hemolytic uremic syndrome associated with a factor H muta acute myeloid leukemia with high white cell counts but does tion. Differential impact of complement mutations on with acute myelogenous leukemia and hyperleukocytosis clinical characteristics in atypical hemolytic uremic syndrome. Early complications in children with acute lympho pneumococcal infection and T activation treated successfully blastic leukemia presenting with hyperleukocytosis. Ther Apher pre-transplant management of a patient with anti-factor H auto 2002;6:15–23. Blood Ferrell G, Del-Favero J, Plaisance S, Claes B, Lambrechts D, 2001;97:2121–2129. Shiga toxin-associated hemolytic uremic syndrome and and promyelocytes in the development of leukostasis syn thrombotic thrombocytopenic purpura: distinct mechanisms of drome. Management of familial hypertriglyceridemia during leukocytic adult acute myeloid leukaemia: a single-center pregnancy with plasma exchange. Leukapheresis and cranial irradiation in patients with with immunoglobulin abnormalities. Semin Hematol 1973;10: hyperleukocytic acute myeloid leukemia: no impact on early 113–124. Plasmapheresis therapy in macroglobu hyperleukocytic leukaemias—the experience of a tertiary insti linemia. Impact of pre-induction therapy leukapheresis on treatment removing abnormal protein rapidly from patients with malig outcome in adult acute myelogenous leukemia presenting with nant paraproteinaemias. Mod A, Fust G, Harsanyi V, Natonek K, Poros A, Szabo J, leukemia with hyperleukocytosis. Ef tions and outcome of children with acute lymphoblastic leuke ficacy of discontinuous flow centrifugation compared with cas mia. Intensive, Waldenstrom and multiple myeloma: influence on blood rheology long-term plasma exchange therapy for severe hypertriglyceri and the microcirculation. Adv Intern of plasma exchange by plasma separation and cascade filtra Med 1992;37:249–273. Pan ultrasound investigation of the therapeutic effect of plasma creas 1996;13:96–99. Swoboda K, Derfler K, Koppensteiner R, Langer M, Pam toma): a case of central retinal artery occlusion. Gastroenterology 1993;104:1527– globlinaemia: modified plasmapheresis as treatment option in a 1531. Plasmapheresis for severe lipemia: tion, treatment, and outcome in patients with Waldenstrom’s comparison of serum-lipid clearance rates for the plasma macroglobulinemia: a two-institution study. 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There is considerable evidence that tobacco smoking is asso ciated with an increased risk of rheumatoid arthritisand with an increased prevalence of rheumatoid factor among people without clinical disease spa hair treatment cheap primaquine 15 mg with mastercard. The role of occupational exposure to daughter medicine generic 15mg primaquine visa silica dust in rheumatoid arthritisis also an active area of research (see chapter 8) medicine man dispensary cheapest primaquine. A recent study in the United States estimated the disease prevalence to symptoms nervous breakdown purchase primaquine 15 mg without a prescription be approximately 25 per 100 000 (Mayes et al. The diagnosis may be hampered when the visceral complaints (predominantly in lungs, heart, and kidney) are not associated with classic skin changes and Raynaud phenomenon. The diagnosis may be supported by detection of anticentromere antibodies (80–96%), common in patients with limited systemic sclerosis, or anti-topoisomerase 1 (Scl-70) antibodies, typically seen in patients with diffuse systemic sclerosis (30–40%). The pathological changes in skin biopsies of systemic sclerosis patients reveal thinning of the epidermis with flattening of the rete pegs, atrophy of the dermal appendages, hyalinization and fibrosis of arterioles, and massive accumulation of dense collagen in the reticular dermis. Also in the visceral organs, the triad of fibrosis, narrowing of blood vessels, and perivascular inflammation is observed, eventually resulting in end-stage atrophy of the affected organs. In particular, the T cell population in affected systemic sclerosis tissues is believed to release cytokines, which initiate and/or perpetuate the fibrotic process as well as the endo thelial and vascular alterations (Derk & Jimenez, 2003). Initially, this cytokine may be produced by infiltrated leukocytes, and production may be further enhanced by sensitized fibroblasts. Altogether, because of the pro gressive fibrosis and organ failure, diffuse systemic sclerosis in particular is associated with a high mortality rate, with an estimated five-year survival of approximately 40%. A fairly strong and consistent association between exposure, primarily in occupational settings, to solvents. Scleroderma-like diseases can also be induced by other chemical compounds, such as drugs (D’Cruz, 2000) and silica (“Erasmus syndrome”). Workers exposed to vinyl chloride monomers exhibit clinical features that resemble systemic sclerosis, such as fibrotic skin lesions, pulmonary fibrosis, and skin capillary abnormalities. However, vinyl chloride disease also harbours several features that are clearly distinct from systemic sclerosis. After exposure is discontinued, skin lesions, capillary abnormalities, and acroosteolytic lesions revert to nearly normal (Haustein & Ziegler, 1985). Scleroderma-like manifestation is a typical clinical feature of the toxic oil syndrome (see chapter 7). Some data also suggest an increased risk of systemic sclerosis in workers exposed to hand-transmitted vibration due to the use of vibrating tools (Bovenzi et al. The diminished gland secretion results in keratoconjunctivitis sicca and xerostomia. Primary Sjogren syn drome is diagnosed if no other autoimmune disease is present; secondary Sjogren syndrome is associated with rheumatoid arthritis or other connective tissue disorders. Like many other connective tissue diseases, there is a female preponderance, with a female to male ratio of 9:1. Patients typically present with dry eyes and mouth, but other mucosal sites may also be affected. Further more, a majority may present with systemic complaints, such as arthralgias, fibromyalgia, or chronic fatigue. Quantitative immunohistological criteria based on percentages of IgA and IgG-containing plasma cells are, however, more sensitive and specific for the diagnosis of Sjogren syndrome (Bodeutsch et al. Although the patho genesis of this disease is still ill defined, it has been suggested that infiltrating lymphocytes induce destruction of the mucosal glands, eventually resulting in the dryness of these mucosal sites. Alter natively, autoantibodies to the M3 muscarinic acetylcholine recep tors may be the causative agents (Yamamoto, 2003). Circulating immune complexes, in contrast, are held responsible for the systemic manifestations. So far, no definite genetic markers have been iden tified for predisposition to Sjogren syndrome. In the long term, patients with Sjogren syndrome are at risk of developing mucosa associated B cell lymphomas, probably due to chronic stimulation of the humoral immune system. Drug-induced lupus (lupus syndrome) is a different disease with more or less similar clinical manifestations. Systemic lupus erythematosus has a clear female preponderance (female to male ratio is 9:1). Furthermore, systemic lupus erythematosus is more prevalent in African Americans and Asians than in Caucasians. In addition to constitutional symptoms, such as fever, weight loss, and malaise, nearly every organ system can be involved. Owing to marked interindividual variability in the clinical expression of the disease, a list of 11 clinical criteria has been proposed, of which 4 must be satisfied for the diagnosis. Since antiphospholipid syndrome is frequently encountered in patients with systemic lupus erythematosus, antiphospholipid syndrome associated autoantibody detection is relevant for recognition of this syndrome. Furthermore, systemic lupus erythematosus follows a course of exacerbations and remissions. Auto antibodies appear to play a key role in the pathogenesis of systemic lupus erythematosus. All antinuclear autoantibodies are probably the result of inappropriate removal of apoptotic material in systemic lupus erythematosus, eventually resulting in an immune response to these normally sequestered autoantigens. Next, the tissue deposition of antibodies and immune complexes could cause inflammation and injury of multiple organs. The pathogenicity of autoantibodies is probably the best proven by the occurrence of neonatal lupus and congenital complete heart block. Since systemic lupus erythema tosus is primarily an immune complex-mediated disease, it is evident that deficiencies and/or polymorphisms in genes of the complement system and the Fc receptors are associated with systemic lupus erythematosus (Tsao, 2003). There are rare instances where systemic lupus erythematosus can be more prevalent in exposed human subjects. However, systemic lupus erythematosus is only infrequently observed in these patients (De Rycke et al. Clear differences between systemic lupus erythematosus and lupus syndrome can be identified — hence the recommended different terminology. Involvement of the kidney or the central nervous system hardly ever occurs, whereas pleural and pericardial effusions are far more frequent in lupus syndrome than in systemic lupus erythema tosus. Circulating antibodies are often directed to histones in lupus syndrome instead of the classical antinuclear antibodies associated with systemic lupus erythematosus. Importantly, discontinuation of the drug typically results in resolution of the clinical findings in patients with lupus syndrome. Abnormal bleeding asso ciated with thrombocytopenia is characterized by spontaneous skin purpura, mucosal haemorrhage, and prolonged bleeding after trauma. Thrombocytopenia may be due to many different causes; here, we discuss only the immune-mediated diseases that are not secondary to systemic lupus erythematosus, malignancy, or infec tion. Adult immune (idiopathic) thrombo cytopenic purpura has a female to male ratio of 2:1. The major cause of fatal bleeding, especially in people over 60 years of age, is intracranial haemorrhage. The involvement of these 80 Clinical Expression of Human Autoimmune Diseases antibodies in the pathogenesis is well established, since transient thrombocytopenia occurs in neonates born to affected women. IgG sensitized platelets are prematurely removed from the circulation by macrophages, especially in the spleen, reducing the lifespan of a platelet to only a few hours. Additionally, the IgG-sensitized plate lets may be destroyed via complement-mediated lysis. Diagnosis is 9 based on low platelet counts (10–50 10 per litre), but normal white cell counts and haemoglobin concentration. The bone marrow shows normal or increased numbers of megakaryocytes, and IgG autoantibodies may be demonstrated on the platelet surface or in the serum. The clinical syndrome is manifested by thrombocytopenia, microangiopathic haemolytic anaemia, fever, renal dysfunction, and neurological abnormalities. The deficiency may be due to genetic mutations (familial thrombotic thrombocytopenic purpura) or autoimmune inhibitors (acquired thrombotic thrombocytopenic purpura). Detection of an inhibitor, which has been identified as IgG, can distinguish familial from acquired thrombotic thrombocytopenic purpura (Tsai & Lian, 1998). Other examples are sulfonamides, thiazide diuretics, chlorpropamide, quinidine, and gold.

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