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Harm and Seidenberg’s simulations showed that the more younger controls when words were presented in context but not severe the impairment that they imposed on the phonological when they were presented in isolation cholesterol test at walgreens purchase lasuna 60caps free shipping. In the case of the iment suggest that dyslexic readers may be able to cholesterol free diet foods order cheapest lasuna and lasuna compensate for most severe impairments cholesterol levels chart age purchase 60 caps lasuna with amex, exception word reading was also afdecoding deficits to kind of cholesterol in eggs purchase lasuna line some extent by relying on contextual cues to fected. In contrast, altering the learning parameter to a nonoptimal support decoding processes. In terms of the triangle model, selevel affected the model’s capacity to read exception words, with mantic activation from the sentence frame primes the semantic a lesser effect on nonword reading. It can be predicted therefore that, given equivalent levels profile at the single-word level. In contrast, an Contrary to this hypothesis, Goulandris, Snowling, and Walker environmental measure of the child’s familiarity with books was a (2000) reported that when compared with children who had a predictor of individual differences in exception word reading. Naucler and Magnusson (2002) Learning to Read: the Role of Nonphonological obtained similar findings in a Swedish sample. To account for such Language Skills counterintuitive results, it is important to note that a division of labor toward the semantic pathway (as posited for dyslexia), alWe have emphasized that in addition to the role of phonology in though facilitating reading, could have a deleterious effect on a learning to read, there are also other sources of individual variachild’s capacity to learn orthographic sequences. The reason for tion, notably a child’s semantic skills and ability to use linguistic this is that orthographic learning in an alphabetic system in which context (Nation & Snowling, 1998a), as illustrated in the extended spelling units connect to phonemes depends on setting up fineversion of the Seidenberg and McClelland (1989) model in Figgrained connections between orthography and phonology. In addition, reading comprehenchild is not using this phonological pathway but rather is relying sion skills that depend on the integration of concepts activated by on context, connections will be formed at a coarser level between the text (Kintsch, 1998) will also be affected. Such influence on the outcome of the child’s literacy development learning is not sufficient to subserve English spelling or to read involves interactions within the developing reading system itself. Furthermore, just as emphasis of much research on dyslexia, and many intervention the use of compensatory reading strategies has a deleterious impact approaches, has been on phonological processes. In a similar vein, the spelling of children simply “corrected for” in a statistical analysis and treated more like with hearing impairments is often better developed than their nuisance variables than important causal factors. In contrast, the reading skills predict (Burden & Campbell, 1994), perhaps betriangle model of reading development emphasizes the interplay cause their attention is directed more to the visual aspects of between semantic, phonological, and orthographic skills, and thus printed words than is the case among children with more proficient restores semantics to a central position. In line with logical language processes are impaired, thus impeding developthis view, Snowling et al. Therefore, reading needs to be thought of as a dycomprehenders would meet a traditional psychometric definition namic system, and its development multicausal. Nevertheless, they are typically severe literacy problems because of the division of labor between children who have never been referred for language assessment. And in older children with developmenof deficit is midway between the categories we have listed. We tal dyslexia, it is often possible to demonstrate impairments on oral also stress that this diagram has been devised to capture the most language tasks that do not involve any reading or writing. Other variables, such as visual perception, as characteristic of developmental dyslexia. It is easy to see why speed of processing, and attention may play a role in literacy there has been a growing trend to collapse these diagnostic catedevelopment for some children. These comprehension difficulties had a different pattern of structural include studies of preschool predictors of literacy development, brain characteristics from those with specific phonological deficits. The quadrant model provides a useful framework for thinking Within this view, surface and phonological dyslexia are on a about subtypes of reading impairment and their relation to lancontinuum of severity (Griffiths & Snowling, 2002) within Quadguage difficulties, but it is nevertheless an oversimplification. One rant A, bearing in mind that cognitive and experiential factors may goal for future research will be to unpack the concepts of phonomodify their behavioral expression. According to Stanovich and ple, when considering what is meant by phonological deficit reSiegel (1994) these children share the phonological deficits of searchers can distinguish between underspecified phonological dyslexia but have additional cognitive problems, including poor representations, difficulty in segmentation, rapid decay of repreworking memory and difficulties with oral cloze and sentence sentations, and problems in learning and automatizing mappings construction tasks, suggesting they fall on a continuum of language between phonology and orthography. Swan and Goswami (1997a) reported that backward stress the reciprocal nature of the relationship between phonologreaders performed at the same level as children with dyslexia on ical and orthographic representations, which includes an influence phonological awareness tasks and had similar problems with word of literacy skill on the nature of phonological representations, as retrieval mechanisms for naming. The nonphonological language dimension lems were associated with vocabulary deficits, whereas those of subsumes a wide range of underlying skills that may make disthe children with dyslexia were not (Swan & Goswami, 1997b). Beargued that syntactic and discourse skills also impinge on learning cause, to our knowledge, no study has assessed the language skills to read and write and on reading comprehension. Where syntactic of backward readers comprehensively, it is difficult to ascertain the difficulties have been found in association with literacy deficits, severity of their nonphonological language problems. Implications for Diagnosis, Assessment, and Intervention Subtypes of Reading Disorder the conventional psychometric discrepancy definition of dyslexia will not identify in which quadrant of the model a child falls. The traditional distinction between phonological and surface If we were to treat as dyslexic any children with poor reading dyslexia does not map neatly onto the quadrant model shown in accuracy or comprehension in the context of normal performance Figure 1. Surface dyslexia is a pattern of behavior that (1997) and others, and equate dyslexia with poor phonological is observed when reading single words with no time pressure. Overall, the procedyslexia can read nonwords accurately given unlimited time and dure we adopt should depend on the purpose of the diagnostic read exception words as though they were regular words (making exercise. However, we argue that in both research and clinical the regularization errors;. However, contexts it will usually be helpful to distinguish between Quadwhen people are required to read under time pressure, the tendency rants A, C, and D. For instance, children with severe and selective to make regularization errors declines (Hendriks & Kolk, 1997). Furthermore, surface more global impairments affecting all aspects of oral as well as dyslexia in children has been associated variously with the overuse written language (see also Morris et al. Moreover, children who show the rizing children, then the most obvious approach to assessment profile are not free of phonological difficulties, although these are would be to use measures that directly tap the two key dimensions milder than in phonological dyslexia (Manis et al. A parsimonious explanation is that the surface profile possible reciprocal influence of (poor) reading on phoneme awareis seen in children with mild phonological impairments whose ness, the assessment of phonological skills should go beyond slow speed of processing compromises the ability to establish metalinguistic tasks and include tests of phonological memory, orthographic representations and who by default use the phonosuch as nonword repetition. Desensitivity would be useful (for illustrative examples, see Lum et velopmental Psychobiology, 40, 278–292. Phonological comparing listening comprehension with reading comprehension awareness and literacy development in children with expressive phonowill also aid the differential diagnosis of classic dyslexia, in which logical impairments. Comprehension of spoken, written, and signed ing is poor for both aural and written materials (Bishop & Adams, sentences in childhood language disorders. Is specific language impairment a valid diagnosbody of evidence suggesting that, while training in phonological tic categoryfi Hove, England: with training in letter knowledge and word reading and the linkPsychology Press. Cerebellar abnormalities in developmental tive for the development of word-level decoding skills of backdyslexia: Cause, correlate or consequencefi Journal of Communication Disorders, 35, 311– that not all readers respond well to such programs of intervention 328. Taken together, these findings raise the issue of relationship between specific language impairment, phonological disorwhether some poor readers, whose phonological difficulties are ders and reading retardation. Journal of Child Psychology and Psychieither severe or complex (co-occurring with nonphonological defatry, 31, 1027–1050. Comprehension problems in children with specific language impairment: Literal and inferential 2003). Programs that neglect verbal skills beyond phonology run the Medical Genetics: Part B. Different origin of auditory and phonological processintervention to support the development of word recognition ing problems in children with language impairment: Evidence from a would seem to be timely (Norbury & Chiat, 2000), and these may twin study. Journal of Speech, Language, and Hearing Research, 42, go some way toward addressing the issue of “difficult-to155–168. Verbal-performance discrepancies: Relationship to birth risk and specific reading retardation. Beginning to read: Thinking and learning about Auditory temporal processing impairment: Neither necessary nor suffiprint. Preschoolers with into residual language deficits: A study of children with persistent and language disorders: 10 years later. Preschool language disorders and a behavioral marker for inherited language impairment: Evidence from subsequent language and academic difficulties. A major susceptibility locus for International Journal of Language and Communication Disorders, 36, specific language impairment is located on 13q21. Journal of Experimental of children attending infant language units: Outcomes at 11 years of age. Mental Retardation and Developmental Disabilities Research Rethe born deaf: An experimental study of deaf school leavers.

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The National Pollutant Inventory notes that primary sources of sulphuric acid emissions in Australia are 7 the industries that manufacture it or use it in production printable list of cholesterol lowering foods buy lasuna cheap. Some of the industries that use it in production are the metal smelters cholesterol in cage free eggs order lasuna 60caps with visa, phosphate fertiliser producers cholesterol medication guidelines generic lasuna 60caps with mastercard, oil refiners cholesterol level medication required order lasuna toronto, the chemical industry, battery manufacturers, manufacturers or fabricated metal products, manufacturers of electronic components, and manufacturers of measuring and controlling devices. Foster et al (1996) conducted a study of exposures, control methods and the occurrence of respiratory symptoms associated with sulphuric acid mist in a selection of Australian industries. Ninetyfifour personal and 134 static air samples were collected in 13 workplaces representing leadfi acid battery manufacture, metal refining, fertiliser manufacture, electroplating and wool carbonising. The highest airborne concentrations were found in leadfiacid battery manufacture, with mean personal exposures ranging from 0. The geometric means of the exposure levels for the workers in the two cell houses were 0. They also estimated previous exposures to sulphuric acid by simulating the process 3 3 3 conditions from before 1975, by removing the foam layer from the electrolyte surface. Under these conditions, the concentration of sulphuric acid mist increased from 0. Thus, today’s exposure levels appear to 3 be lower than those reported to be associated with an increased prevalence of laryngeal cancer in other industries, but the levels prior to 1975 seem to have been much higher. By mass, most of the inhalable aerosol was in the size fractions considered to be highly relevant for the effects of sulphuric acid on the respiratory system. The highest sulphuric acid concentrations by the cascade impactor were obtained at the sulphuric acid pump tank area. The geometric mean (±geometric standard deviation) for 3 7 Available from. Sulphuric acid mist concentrations varied 3 significantly among the plants and even at the same location. Risk of health effects Review of health outcomes, both malignant and nonfimalignant respiratory disease, with the level of exposure of workers exposed to sulphuric acid mist is required. Much of the work reported to date is dated with very little or no assessment of exposure. Of these only 5 were published in the past decade, and of these 2 were reviews which presented no new data and 2 were extensions of previous studies. Such effects can be manifested as sensory irritation of nerve endings, acute or longer term inflammation at various sites along the length of the respiratory tract epithelium, and ultimately the possibility of tumour formation in the respiratory tract, believed to be a consequence of sustained tissue inflammation and repair processes. Animal studies Kilgour et al (2002) exposed Wistar rats to 50% sulphuric acid aerosols at 0. There were dosefirelated changes and significant cell proliferation to laryngeal cells at the higher doses after 5 and 28 days and minimal changes at the lower dose after 28 days. Recovery was partial after 8 days and only limited additional recovery was observed after 4 weeks. A review of chronic toxicity and carcinogenicity in animals was conducted by Swenberg and Beauchamp (1997). Groups of cynomolgus monkeys exposed to sulphuric acid mist for 78 weeks showed reduced lung function and changes in the lung and bronchioles at 2. Although pulmonary function was impaired, 3 3 no histopathological changes were evident in eight dogs exposed at 0. In another study 3 Syrian hamsters were exposed to either benzo(a)pyrene and or sulphuric acid mist. Swenberg and Beauchamp (1997) concluded that the study did not show any evidence of carcinogenic activity and was considered equivocal for coficarcinogenic or promoting activity. Human studies – cancer studies Lynch et al (1979) investigated the mortality and morbidity of respiratory cancer, in particular cancer of the larynx, in workers at alcohol manufacturing plants. The plants used sulphuric acid at either 99% or 60% to 70% (strong acid or weak acid process). No measures of exposure were available for any of the workplace contaminants and the authors used man months of employment in either the strong acid or the weak acid plant. Additionally 3 of the 4 cases spent more than 70% of their time in the ethanol (strong acid) plant compared to less than 20% for the cohort as a whole. The authors concluded that exposure to one of the agents in the strong acid plant resulted in a higher incidence of laryngeal cancer and thought dimethyl sulphate was most likely. Cancer mortality was studied in two leadfiacid battery manufacturing plants and in two steel works involving a cohort of 4401 men (Coggon et al, 1996). In one leadfiacid battery plant, fixed position sulphuric acid monitoring was carried out sporadically from the 1970s. No indication is given of the number 3 of exposure measurements or how they were taken or analysed. For the steel plants, no workplace monitoring data is available, although the authors note that some people were not able to tolerate the levels in certain areas. No excess of lung or laryngeal cancer was observed and no differences in rates were observed between workers definitely exposed to acid mist and those definitely not exposed. A study of Italian soap makers (Forastiere et al, 1987) found the incidence of, but not mortality from, squamous laryngeal cancers to be significantly elevated; 5 observed versus from 0. After correcting for alcohol consumption and smoking a standard 3 incidence ratio of about 2. The incidence was not related to duration of exposure or time since first employment. A nested case control study confirmed the lack of trend with duration and the odds ratio for 10 years exposure versus 6 months exposure was 0. Soskolne et al (1992) conducted a case referent, population based interview study of confirmed laryngeal cancer cases in Southern Ontario. The study matched 204 people who had laryngeal cancer with referent for age, gender and neighbourhood of residence. The work history of each of the 408 people was ascertained by interview and exposure to sulphuric acid mist estimated by knowledge of the exposures associated with each job. They found that laryngeal cancer was significantly more likely in people who had worked with sulphuric acid with the risk apparently related to higher concentrations and longer periods of exposure. The effect of the different summary work life exposure measures was investigated by SuarezfiAlmazore et al (1992), who reviewed the Baton Rouge (Lynch et al, 1979) and Southern Ontario (Soskolne et al, 1992) studies. For the Baton Rouge cohort odds ratios for upper respiratory tract cancer and exposure to sulphuric acid mist varied from 0. Only mean grade for moderately exposed and highest ever exposure for high exposure achieved significance. In the case of the Southern Ontario study the odds ratios for the different measures for low exposure varied from 1. The authors suggested that where no exposure data are available, the summary exposure metric selected could have a profound effect on study outcome. Sathiakulmar et al (1997) undertook a review of 25 epidemiological studies of the carcinogenicity of sulphuric acid mist. Based on studies in the production of sulphuric acid, isopropanol, soap and detergent, synthetic ethanol, phosphate fertilisers, nitric acid and lead batteries and in copper and zinc refining and metal pickling they concluded that: fi There is no persuasive evidence that a causal relationship exists between sulphuric acid mist and lung cancer. In the case of lung cancer they observed that the magnitude of positive associations were weak and inconsistent, could be readily explained by known confounding exposures and lacked clear dose response trends. In the case of larynx cancer the associations were stronger and on aggregation of the studies the association was stronger in industries which have higher potential exposure levels. It should be noted that other risk factors for laryngeal cancer are heavy alcohol and tobacco use, and low intake of fruit and vegetables or Betafi carotene (Parent et al, 2000). Human studies – non cancer studies Grasel et al (2003) reported on clinical and histopathological findings in 52 process workers from 5 anodising plants in Sao Paulo in Brazil. Following statistical analysis of the results the geometric mean was 3 3 presented, which is of limited use for interpretation. Histopathological evaluation showed workers exposed to sulphuric acid mist had significantly more abnormalities than unexposed workers. There was no association with age, smoking habits or exposure duration with the parameters measured, however a strong association was found with exposure level. The response of 12 healthy volunteers to inhalation of sulphuric acid mist and sodium chloride (NaCl) at 1 mg/m was investigated by Frampton 3 et al (1992).

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Both tasks that is based solely on a semantics versus phonology conentail processing of the printed word and making a judgtinuum cholesterol lowering diet plan chart order lasuna online now. In the other cholesterol ratio 3.3 buy discount lasuna 60caps on line, they passively presented participants with three sorts of sentences that listened to cholesterol ratio test generic 60caps lasuna free shipping the sentences lowering cholesterol and diet discount 60caps lasuna free shipping. Indeed, Expanding on the issue of structural complexity, some quite a few other regions have been identified in the literaresearchers have put forward the stronger claim that certain ture: Wagner et al. It is reasonable to assume that on the neural ment in this very specific type of syntactic processing. Yet, level, accessing a word is more efficient when the word’s a detailed examination of the results reveals an interestmeaning has been recently primed. This logic has lead to ing pattern: in both regions, sentences with transformaa number of investigations into the neural mechanisms tions showed above-baseline activity, but sentences without underlying semantic priming: specifically, brain regions transformations showed below-baseline activity. This patshowing less activity for primed than unprimed words tern is intriguing; if these regions were indeed involved in have been linked to semantic retrieval of words’ meanings. Similar findings are these words was compared to that of a word semantically seen in a study where participants were presented with either unrelated to bank. In this study, only the most difficult condition, consistsome have also revealed facilitation in temporal cortex (cf. There is much less debate on whether there are than a qualitative increase in activity that is related to synbrain regions particularly important for semantic processtactic complexity. On system constructs the meaning of sentences, and to the a more general interpretation, syntactic difficulty increases nature of the end product that results. Thus, there is considerable in meaning construction, (c) understanding the processing debate on the explanation of syntactic transformation effects, of literal and non-literal meanings or (d) studying if senand future research is needed to address this issue. In one One method that may identify brain regions involved in of the conditions these statements had different syntactic semantic processing is to present sentences in visual and forms. This a particularly important role in the integration of semantic finding supports the purported dissociation between posteand syntactic processes. Currently, the results of such studies support a role for temporal Does the comprehension of action sentences rely on aregions in sentential semantics. This of sentences or mixed-word lists to their repeated presentalongstanding question in cognitive science has been recently tion. They found decreased activity in cortical areas includaddressed by neuroimaging studies. Thus, tial and repeated presentations was 44 min, which could in humans this region may code actions at a level that is have contributed to diminished accessibility of the sentence abstract enough to be accessible to language. Repetition of both types of sentences entially sensitive to observation of mouth, foot and hand was associated with reduced activity bilaterally in tempoactions are also differentially sensitive to sentences menral regions. However, in the right lingual gyrus they found tioning actions performed by these effectors (Aziz-Zadeh decreased activity for repetition of non-subordinate-clause et al. Such studies suggest that language compresentences, but repetition enhancement for repetition of subhension, at least in the action domain, is supported by motor ordinate-clause sentences. Congruent embodied representations for visually presented actions and linguistic phrases describing actions. Listening to action-related sentences discourse entails discourse-level processes that are absent activates fronto-parietal motor circuits. The understanding of the neural underpinnings of these processes is only in its Semantic integration processes have also been studied by initial stages. Temporal regions in the right hemisphere showed particularly sensitive to the differences between normaland greater activity for untitled than for titled stories, but meaning-violated sentences, but the fusiform gyrus was also temporal regions on the left showed the opposite pattern. As reviewed, extracting speech a text’s meaning resulted in increased activation in medial categories from the auditory input may rely on general brain regions. Similarly, accessing semantic knowledge via narratives versus unlinked sentences, Xu et al. On the seems to affect the anatomical pattern of results more than discourse level, establishing consistency or inconsistency does the presence of textual clarification per se. Thus, understanding the relation between language establishing a causal link between two sentences were first comprehension and related domains would be an essential examined by Mason and Just (2004), who presented pairs of step towards establishing what types of neural processing sentences varying in causal strength. When the sentences were hand gestures or face movements affect the neural processmoderately related (as opposed to highly related or distantly ing of language. The presence of gestures can serve to related) these regions demonstrated the greatest number of emphasize or add to information conveyed verbally. In that study, it was the moderate-link condithe presence of gesture will result in increased activity in tion that most strongly demanded construction of a causal certain regions (as more information is processed), but less scenario from world knowledge. Yet, a different study using a activity in others, as interpretation per se may be easier. The chalduring reading are associated with increased activity in lenges facing this research in the future are interesting, midline and right temporal regions (Speer et al. Activation of auditory cortex during silent lishing how and whether language processing capitalizes lipreading. Semantic memory and the brain: functional magnetic resonance imaging of crossmodal binding in the Structure and processes. Functional specialization for semantic and phosyntax and semantics in sentence comprehension. Semantic encoding and retrieval in the left infeing of “ what ” and “ where ” in auditory cortex. Listening to talking processing: Syntactic integration versus syntactic working memory. Human brain activity the role of left inferior frontal and superior temporal cortex in sentime-locked to narrative event boundaries. Psychological Science, 18, tence comprehension: Localizing syntactic and semantic processes. Task-specific repetition priming in left inferior prefrontal cornatural language. The functional neuAn examination of brain regions involved in the integration of discourse roanatomy of comprehension and memory: the importance of prior contents, and their encoding to memory. Language in context: Emergent features of word, sentence, and narraA review of higher level language comprehension with emphasis on the tive comprehension. Meta-analyzing left hemisphere language areas: Phonology, semantics, and sentence processing. An analysis of data from 129 scientific reports of neural activity during language processing, broadly defined. Thanks to their ability to provide continuous online question answered there are new questions raised; we address some measures with an excellent temporal resolution, even in of these yet unresolved questions as well. The fact is there are practical benefits, such as the newly spective of real-time brain dynamics underlying linguistic developed ability to assess cognitive abilities in non-communicaoperations. We will outline the factors that infiuence these brain responses, and by inference, the linguistic processes they refiect. Animal models are of limited element of component discovery since the first “ language ” value given that no other species has a comparably complex component, the “ semantic ” N400, was observed (Kutas & communication system. Handbook of the Neuroscience of Language 91 All rights of reproduction in any form reserved. Other comonset effects on the N100 were examined as a function of ponents refiect integration or revision processes and tend to word stress with the finding that stressed syllables evoked have larger latencies (up to 1 s). Such an effect was expected A recent theme that has gained increasing prominence is given the physical differences that exist between stressed the degree to which these “linguistic” components are actually and unstressed syllables. Most of them have been described initially N100 was monitoring more than the physical characteristics as being related to language processes only. However, subof the stressed and unstressed syllables because the N100 to sequent research has usually weakened the case for domain these stimuli showed a different scalp distribution compared specificity. For example, the P600 (Osterhout & Holcomb, to that seen for the N100 to word onset and word medial syl1992) had been linked to syntactic processing. The conclusion was made as domain-non-specific responses that refiect basic operations that non-native speakers do not use the acoustic differences critical for, but not limited to, linguistics processes. Although these effects require replication as a final confirmation, they nevertheless demonstrate 9.

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Great emphasis was placed on completing the genome project to remnant cholesterol definition generic lasuna 60 caps online make the twenty-first century the ‘century of biology’ cholesterol well gummies order lasuna 60caps without prescription. There may be many mechanisms at play cholesterol levels uk purchase lasuna 60caps on line, to high cholesterol chart uk order lasuna no prescription various degrees, regarding radiobiological effects across the entire dose schedule range, and across dose encompassed tissues [24. Gradients and transitions in mechanisms need to be further exploited for benefit, but finding funding for these may be problematic. In contrast, critical technological and engineering developments in the past few decades have been commercially viable. These have been in imaging (including electron density, map based volume planning) and computing (including higher resolution imaging, dose sculpting and strong beam collimator controls). Consequently, these have come to the fore in high income countries, revolutionizing radiation oncology in some centres. However, many regions and countries have few radiation facilities and continue to manage patients with relatively simple radiation methods [24. Simple plans and equipment can certainly cure many patients of cancer, so the extent to which all centres in the world and all patients need to migrate towards complex planning and delivery systems is unclear, although we are far from a stopping point today. It is absolutely necessary for supranational, not for profit agencies to expand research in radiation oncology at those levels. National economies are developing, centres are improving and increasing in number, and the number of newly trained clinical staff is growing. Unnecessary local barriers to research should be reduced and research should be accelerated by building infrastructure. National cancer control strategies are important, but a shared vision in, and greater practical support from, countries for regional, continental and international research is also needed. It should not be that each country develops completely separate programmes of research; that would be inefficient and it would not leverage existing knowledge and resources. Duplication (as distinct from replication) is not a luxury but a waste of resources. These must be encouraged and supported by communities of countries and their representatives and associated agencies. In addition to providing more funding, countries could streamline ethics approvals. They should also make greater provision for some clinicians to become clinical investigators, with more time per case to comply with protocols, accrue more patients, produce quality results, help to disseminate results, and advocate on behalf of patients and based on research findings. Multicentre international trials need to be of as short a duration as possible, and with sufficient local support to avoid operational failure. There has been a great propensity to conduct clinical studies in small geographical regions, as this is much easier than conducting such studies in large regions. Results from trials conducted in small regions are almost always intended, by sponsors and investigators, to have wide application. But wider application of geographically limited studies is inconsistent, and it is open to challenge [24. It makes more sense to develop methods and conduct comprehensive trials with greater participation over good geographical and socio-demographic ranges, to explore heterogeneity and to expedite knowledge transfer and uptake of research findings. One can only conclude that existing methods of investigator collaboration are insufficient. Greater interactive social and collaborative networks of investigators, data managers, statisticians and methodologists are possible [24. Furthermore, present educational methods for teaching students and frontline clinicians about research and statistics are not producing junior staff capable of conducting or participating collaboratively in solid local, regional or international research, and of continuing to do so throughout their careers. Learning in-context methods for acquiring knowledge, skills and experience, and having these within networks, may be a solution to this chronic problem [24. It is pointless to globally train investigators for research without also growing a global capacity for good and efficient data management at the regional, continental and international levels. For organizational agility, such centres can act as hubs for studies, training and research about research. Later they can be portals for emergent studies testing new gene, protein and nanomaterial agents at a time when venture capital will find a need to support research in radiation oncology. It represents the best of enlightenment ideals as expressed in the natural sciences and applied to clinical care and cancer survivorship. Radiation oncology has advanced steadily by careful scientific and clinical research, with important commercial pressure mediated by technology and engineering. The field of radiation medicine has become dynamic at a time when radiation treatments will be more widely needed. Age, co-morbidities and concurrent agents necessitate that radiation be optimized for safety and efficacy, using all available tools and technologies. Good research questions, answered with good methods, can have a great impact in this second century of radiotherapy. It needs to include in-context research training; a supportive and engaged network of data management and methods centres; greater standardization and efficiencies in training and data management; more assistance from institutions, organizations and countries; and collaborative networking. Prospective studies, clinical and outcome registries, and randomized controlled trials are required to meet the challenge of the cancer epidemic by providing focused, definitive evidence in support of making wise clinical and politico–economic decisions about patient care and cancer control. Radiotherapy will remain one of the most important modalities to treat cancer for another generation. A network of data management and methods centres could be an innovative way to support studies, registries and trials in radiation oncology. Teaching Statistics Ljubljana, 2010), International Association of Statistics Education, the Hague (2010). Rasmi the population in the Middle East region was approximately 300 248 000 in 2010 [25. More than 50% of the population is under 25 years of age, while only 1fi5% is above 60 years of age. The incidence of cancer is lower than in more developed regions, varying from 50 to 190 cases per 100 000 population [25. Given that approximately 50% of patients need radiotherapy and 25% may need additional treatment (re-treatment), around 184 000–203 000 patients per year are estimated to need radiotherapy treatment for cancer in the region [25. European service planning benchmarks suggested 450 patients per machine per year [25. In Australia and Turkey, the target was set at 400 patients per machine per year [25. The suitable goal for the region could be 450 patients per machine per year, and this is the benchmark used here for our calculations of teletherapy machine needs (Table 25. In addition, up to 25% might receive a second course of radiotherapy in developed countries, but this proportion for developing countries is not known. Therefore, the re-treatment rate is not considered here and the calculated rate should be taken as a minimum. The teletherapy machine throughput (the number of new treatment courses per machine per year) has been estimated at 400 or 500 in India and Belgium. Bahrain, Cyprus, Israel, Jordan, Lebanon, Qatar and Turkey exceed the region’s average. The variation in the number of teletherapy machines per 1000 cancer cases per year ranged from 0. Bahrain, Kuwait, Lebanon, Qatar, Saudi Arabia and the United Arab Emirates have 2 or more machines per 1000 cancer cases. A total of 176 simulation imaging devices were also available, and 209 treatment planning systems were recorded. These are located in Saudi Arabia (planned to be operational in 2017) and in Abu Dhabi (planned to be operational in 2018). If, ideally, one radiation oncologist is available for every 250 new patients, then between 736 and 880 radiation oncologists are needed. The number of radiation medical physicists reported was 513, with the ideal level being between 460 and 550. The undersupply or deficit was most noticeable in Yemen, the Syrian Arab Republic and Iraq, with a deficit of 87%, 69% and 58% of their calculated needs, respectively. Jordan, Kuwait, Lebanon, Saudi Arabia and the United Arab Emirates showed an oversupply relative to the calculated demand.

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