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  • Director, the Center for the Study of Motor Learning and Brain Repair
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https://www.hopkinsmedicine.org/profiles/results/directory/profile/9121870/john-krakauer

Education points to arthritis in upper right back best 400 mg trental consider » Focus on the positive aspects of therapy whilst being encouraging regarding the impact of the negative aspects and offer support to arthritis pain remedies discount trental 400mg on line deal with them if they occur arthritis in neck dizziness discount trental 400 mg on-line. Note: Some patient’s lifestyles make certain adverse responses acceptable which others may find intolerable arthritis medication high blood pressure order genuine trental. Sedation is unlikely to be acceptable to a student but an older patient with insomnia may welcome this side effect. However, once the interval is decreased to 3 times a day there is a sharp drop in adherence which deteriorates further on a 4 times a day regimens. Use one of the following: Weight Dose Susp Capsule Age kg mg 125mg 250mg 250 500 Months/years /5mL /5mL mg mg fi8 months–7 fi11–25 kg 250 mg 10 mL 5 mL 1 cap – years fi25 kg 500 mg – – 2 caps 1 cap fi7 years Adults fi Amoxicillin, oral, 500 mg 8 hourly for 5 days. Commonly presents as painful creamy white patches that can be scraped off the tongue and buccal mucosa. Risk factors for candida include: » poor oral hygiene » immunosuppression (may be responsible for severe cases of oral thrush) » prolonged use of broad spectrum antibiotics or corticosteroids (including inhaled) » certain chronic diseases. It is characterised by: » foul smelling breath » necrosis and sloughing of the gum margin, especially of the interdental papillae » loss of gingiva and supporting bone around teeth » presence of underlying disease. Children < 15 years of age 2 fi Aciclovir, oral, 250 mg/m /dose, 8 hourly for 7 days. Children > 15 years of age and adults fi Aciclovir, oral, 400 mg, 8 hourly for 7 days. Symptoms often associated with teething include: » fretfulness » biting or chewing on hard objects » drooling, which may often begin before teething starts » gum swelling and tenderness » refusing food » sleeping problems Teething is not a cause of severe or systemic symptoms, such as high fever or diarrhoea. Exclude conditions other than teething in infants who are systemically unwell or in distress. Advise caregivers to seek medical advice if the infant becomes systemically unwell. Do not use local oral anaesthetic preparations in infants, as these have been associated with severe adverse events. A thorough evaluation is necessary to exclude a surgical abdomen or other serious conditions. The history should include: » duration, location, type, radiation and severity of pain » relieving or aggravating factors. These conditions often present with epigastric discomfort and minimal change in bowel habits. Caused by organisms spreading through the wall of the anus into peri-anal soft tissues. Clinical features include: » rice water appearance of stools: – no blood in stools – no pus in stools – no faecal odour » possible vomiting » rapid severe dehydration Note: Prevent and treat dehydration. In all children who are able to take oral medication fi Zinc (elemental), oral for 14 days: o If < 10 kg give 10 mg/day. The volume of fluid required for oral rehydration depends on the severity of the dehydration. Antibiotic treatment Children fi Ciprofloxacin, oral, 20 mg/kg as a single dose immediately. Constipation may have many causes, including: » incorrect diet (insufficient fibre and fluid) » lack of exercise » pregnancy » old age » medicines. The cause of acute diarrhoea cannot be diagnosed without laboratory investigation. Treatment child is reclassified especially » Instruct the as B: Some breastfeeding. Homemade sugar and salt solution is recommended for home use and to prevent dehydration. Age range Dose Capsule Capsule units 100 000 u 200 000 u Infants 6–11 months old 100 000 1 capsule – Children 12 months to 5 years 200 000 2 capsules 1 capsule Administration of a vitamin A capsule o Cut the narrow end of the capsule with scissors. Giardiasis is a common cause of chronic diarrhoea in adults, and may be difficult to diagnose on stools. Therefore empiric treatment for giardiasis is recommended before referring such patients. If there is no clinical response within three days manage as amoebic dysentery or refer for formal assessment. Antibiotic therapy Indicated for: » Children > 1 year of age and adults with blood in the stools. Infestation may be caused by: » beef tapeworm – Taenia saginata » pork tapeworm – Taenia solium 2. Type of worm Description Signs and symptoms Common Roundworm » Long pink/white worms with » Cough. Short-term treatment with proton pump inhibitors, H2-receptor antagonists and prokinetics for gastro-oesophageal reflux disease-like symptoms and endoscopy negative reflux disease. Clostridium difficile-associated diarrhea and proton pump inhibitor therapy: a meta-analysis. Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years of age. Group for Enteric, Respiratory and Meningeal disease Surveillance in South Africa. A full blood count is not required for children, unless referral criteria above are present. Note: Iron deficiency anaemia in children > 5 years of age, adult males and nonmenstruating women, is generally due to occult or overt blood loss. Foods rich in iron include: liver, kidney, beef, dried beans and peas, green leafy vegetables, fortified wholegrain breads and cereals, cheese. Macrocytic anaemia in these women can be assumed to be due to folate deficiency and does not require further investigation. Vitamin B12 deficiency occurs mainly in middle-aged or older adults, and can cause neurological damage if not treated. Macrocytic anaemia outside of pregnancy or the postpartum period requires further investigations to establish the cause. Folic acid given to patients with vitamin B12 deficiency can mask vitamin B12 deficiency and eventually leads to neurological damage, unless vitamin B12 is also given. Exception Babies who were premature and are growing parallel to or better than the Z-score lines, should not be classified as failure to thrive or not growing well. If the child is able to swallow: fi If breastfed: ask the mother to breastfeed the child, or give expressed breastmilk. To make sugar water: Dissolve 4 level teaspoons of sugar (20 g) in a 200 mL cup of clean water. If the child is not able to swallow: fi Insert a nasogastric tube and check the position of the tube. If blood sugar < 3 mmol/L treat with: fi 10% Glucose: o Nasogastric tube: 10 mL/kg. Age range Dose Capsule Capsule units 100 000 u 200 000 u Infants 6–11 months 100 000 1 capsule – Children 12 months–5 years 200 000 2 capsules 1 capsule fi Multivitamin, oral, daily. Not growing well may be due to: » Insufficient food intake due to anorexia and illness or poor availability of food. Feeding recommendations for all children: 0–6 months of age Breastfeed exclusively feed at least 8 times in 24 hours. If formula is medically indicated (refer below) or if the mother has chosen to formula-feed the child, discuss safe preparation and use with the mother. Children 6–8 months should be given two meals daily, gradually increasing the number of meals so that at 12 months the child is receiving 5 small meals. For children who are not growing well, mix margarine, fat, or oil with their porridge. Give locally available protein at least once a day, and fresh fruit or vegetables twice every day. Maternal medical condition that may justify temporary or permanent avoidance of breastfeeding: » Severe illness that prevents a mother from caring for her infant, for example sepsis, renal failure. Infants who qualify to receive infant formula as part of the supplementation scheme » the mother has died or infant has been abandoned. Age range Dose Capsule Capsule units 100 000 u 200 000 u Infants 6–11 months 100 000 1 capsule – Children 12 months–5 years 200 000 2 capsules 1 capsule 3. If associated with measles and diarrhoea there is an increased risk of illness and death.

Diseases

  • Micrencephaly olivopontocerebellar hypoplasia
  • Narrow oral fissure short stature cone shaped epiphyses
  • Progeroid syndrome, Penttinen type
  • Synovial osteochondromatosis
  • Rambaud Galian syndrome
  • Johanson Blizzard syndrome
  • Chromosome 1, trisomy 1q42 qter

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In which one of the following children would resistance—metformin (10 years) you most suspect hyperthyroidismfi A 14-year-old adolescent female who is heat intolerant and has amenorrhea Questions 345 c arthritis left knee icd 9 buy 400 mg trental mastercard. Is caused by anatomic defects in the brain precocity or incomplete (pseudoprecocity)fi True precocity occurs because of hormonal hypothalamus stimulation from the pituitary or hypob arthritis pain throughout my body discount trental online american express. Results from damage to arthritis pain sleeping buy trental 400mg fast delivery the hypothalamus thalamus causing gonadal maturation and or pituitary from surgical trauma or infection fertility c arthritis symptoms neck upper back purchase trental overnight. Incomplete precocity is caused by adrenal symptom or gonadal tumor or dysfunction and results 9. An infant with polydipsia, polyuria, irritability, in increased linear growth but no developand failure to thrive, should be evaluated for: ment of secondary sex characteristics d. Hyperglycemia arm span, arachnodactyly, laxity of joints, pectus excavatum, and an abnormal echocardiogram 10. Which one of the following is not characteristic would be suspected of having: of constitutional growth delayfi Prominent mandible and supraorbital ridge and microphallus should be suspected of having: c. Increased pigmentation in the axilla, groin, ondary sex characteristics at puberty and who areola, hand creases, and in surgical scars has small, underdeveloped testes should be susc. Which finding is not a sign or symptom of diacharacteristics betes onset in childrenfi Three factors infiuence a child’s potential to develop diabetes—genetic predisposition, 23. Blood glucose levels of children 5 to 11 years autoimmune response, and exposure to with diabetes should be maintained between: viral or chemical agents a. In boys, lack of secondary sexual characteristics glucose in the blood system after 17 years suggests: b. Pituitary adenoma in order to avoid the potential for hypoglycemia with consequent neurological system damage Bibliography 347 31. All of these organizations have web sites is a central contact for the child and family for issues that can be accessed via a search engine. The Alliance of care coordination and community-based intervenof Genetic Support Groups, (202) 966-5557 and tions, advocacy, assistance with stress management, Review history for possible maternal coinprovides a wealth of information for parents of children fections including tuberculosis, syphilis, who have various special healthcare needs. Specific testing is not recommended unless genital diseases and disorders, and the National Inforsuggestive by history or physical assessment mation Center for Children and Youth with Disabilities 4. A single negative test at 8 weeks identifies a presumptively uninfected infant • Definition: Advanced stage of illness in individu7. Infants with positive virologic tests results at or before 48 hours are considered to have been • Differential Diagnosis infected in utero, but infants having a negative 1. Falling ratio of head circumference to height • Prevention Strategies and weight, due to encephalopathic direct 1. Chlamydia trachomatis is the most prevalent months regardless of symptoms, immunosexually transmitted disease in the U. Maternal transmission to neonate from conaureus, Haemophilus infiuenzae, streptococtact with vaginal secretions during birth cus, herpes simplex, enteric bacteria 2. Chemical reaction to silver nitrate infection with 15to 19and 20to 24-year-old 3. Bronchitis/pneumonia—respiratory syncytial women highest rates of gonorrhea in 2007 virus, other viral or bacterial infections 3. Chest radiograph shows hyperinfiation and infiltrates but usually there is no lobar consoli• Differential Diagnosis dations or pleural effusion 1. Skin, oropharyngeal, arthritic, vaginal, urehighly sensitive and specific (95%) and have thral, rectal, systemic infection a rapid turnover; have potential for false posi4. Gonococcal ophthalmia neonatorum—coninfection can be present for up to 18 junctivitis, appearing 2 to 5 days after birth, months; after this, sexual abuse needs to occasionally up to 25 days be considered a. Lower genital tract infection is generally becomes thick, mucoid, sometimes asymptomatic bloody b. Untreated, may progress to edema and ineffective; infants less than 6 months, oral erythulceration of cornea, globe perforation romycin suspension, 40 to 50 mg/kg/day for 10 to and blindness, and/or may become sys14 days; approximately 20% of infants need second temic infection course of treatment; erythromycin is associated 2. Other—scalp abscesses, disseminated infecwith increased risk of pyloric stenosis tion with signs of sepsis, meningitis, or pain, and decrease in motion if septic arthritis Gonococcal Infection (Refer to Gu/Gyn chapter) • Diagnostic Tests/Findings 1. Culture is preferred—swab from orifice or develop symptoms if not immediately treated; blood, synovial fiuid from affected joint or initial presentation up to 2 years of age cerebrospinal fiuid specimen 2. Lymphadenopathy with Coombs-negative nitrate 1% aqueous; erythromycin ophthalmic hemolytic anemia ointment 0. Osteochondritis which causes resistance ment 1% to movement (pseudoparalysis of Parrot) 2. Rash similar to secondary syphilis with disseminated disease desquamation of hands/feet a. Rash stage—pityriasis rosea, scabies, tinea Congenital Syphilis • Physical Findings (Refer to Gu/Gyn chapter) 1. Direct visualization of spirochete by dark early 90s, the rates were as high as 4424 (1991); field microscopy; direct fiuorescent antimore common in South/rural areas body test for Treponema pallidum 2. Treponemal test—fiuorescent treponemal has primary and secondary infection, rather antibody absorbed; microhemagglutinathan latent infection tion assay for antibody to Treponema 4. Coombs negative hemolytic anemia, direct contact of virus with host mucous memthrombocytopenia brane or abraded skin 5. Prenatal screen all pregnant women; treat all • Signs and Symptoms infected individuals, especially sexually active 1. Usually presents in first two weeks of life titer, or has a positive dark field or fiuorescent b. Cutaneous lesions generally located on antibody test of body fiuid with: scalp, mouth, nose and eye with the baby a. Aqueous crystalline penicillin G 100,000– contracted from the mother’s genitals 150,000 units/kg/day, administered as 3. Acutely ill infant during first week of life there is a decrease fourfold in test or the c. Multisystem involvement—shock, distest becomes nonreactive seminated intravascular coagulation, and 3. For children with reactive serologic tests multiorgan failure for syphilis identified after one month, the d. Unresponsive to antibiotic therapy provider should review maternal serology to determine if the child has congenital or • Differential Diagnosis acquired syphilis; treatment consists of: 1. Langerhans cell histiocytosis and incontinen10 days tia pigmenti can present with vesicles b. Follow-up as above for infected neonates • Physical Findings Herpes (Refer to Gu/Gyn chapter) 1. Herpetic skin lesions in 60% of cases sensory ganglia following primary infection b. Sensorineural hearing loss is most comseminated disease mon sequela (Enright & Prober, 2004) with 7. Most common intrauterine infection, affecting age and younger, since both initial infection 1% of newborns and reactivation during pregnancy can cause 2. Prevalence varies with age, socioeconomic stafetal infection tus, ethnicity, and nationality, with increasing a. Of all the congenital infections, only 22% prevalence with age, coming from a developof mothers knew about this infection; eduing nation, low socioeconomic group, and cation is needed being African-American 2. Risk of severe disease is greater if exposed to developmental disabilities center for interdisgestational primary infection however conciplinary management of complex disabilities genital infection can result from reactivation 3. Preterm infants are at greater risk of symptomsorineural hearing evaluation atic infection b. Neonatal acquisition—often presents as afebrile pneumonia after 8-week incubation • Signs and Symptoms period; test suspect infants 1. Blueberry muffin lesions or dermal erythropoiesis • Definition: Multisystem involvement in a neonate 6. Cataracts, retinopathy, glaucoma associated with maternal infection with rubella 7. Petechial or purpuric rash virus; up to 85% of infants are affected if the infec8.

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Given limited resources arthritis in dogs diet discount trental online mastercard, we were unable to arthritis starting in my fingers cheap trental search for articles published in languages other than English rheumatoid arthritis with rash order trental 400mg. However arthritis supplies generic trental 400mg online, we believe that our results are not severely affected by language bias because prominent articles are often translated into English due to the wide readership of this language. This review would have benefited from the inclusion of conference proceedings and master and doctoral theses which are more likely than published articles to present null findings. It is also possible that having a single reviewer could have resulted in the exclusion of some relevant studies. Even though we might not have identified the entire landscape of literature, we are 25 confident that we have included key studies in the field because we used a broad inclusion/ exclusion criteria and, also searched the reference lists of some key papers that met the inclusion criteria. Peer-based interventions that help homeless youth connect with pro-social home-based peers should be considered alongside individual-based programs. Ongoing interventions should focus both on preventing and treating homeless youth who have suffered childhood sexual abuse. Future research needs to critically explore homeless youths’ relationship with family members; employ social network and mixed method approaches that will provide a richer understanding of how social relationships influence behaviors; and, use representative samples and standardized instruments that will allow making comparisons across studies. New York 20 M ean age:, Sex Trade Activerecruitm entbypeers:Youngerand/oryouth (2009). Range: who werelessfam iliarwith thestreeteconom ywere % F em ale often activelyrecruitedintothestreeteconom yby % W hite ‘‘predatory’’adults,andto alesserex tent,byother hom elesspeers M cCarthy Toronto 390 M ean age:, Sex Trade 1. Crim inalstreetassociation hasastrong and andH agan Range: significanteffecton sex trade:Beta. Northwestern Range:13-20 partnersin past3 abuse(prepubertally)wassignificantlyassociated U nitedStates 100% F em ale m onths with sex ualcoercion andsex ualcoercion was 78. Sex ualAbuse:Abusedyouth hadsignificantly Num berof lifetim e m orepartnersin lifetim ethan neverabusedyouth partners [[F (2,168)= 14. Sex ualabuse:Abusedyouth hadsignificantly in pastthreem onths m orepartnersin previousthreem onthsthan never abusedyouth [[F (1,167)= 5. Sex ualAbuse:Abusedyouth weresignificantly m orelikelytoengagein unprotectedsex [F (2,168)= 7. Living situation in fam ilysetting (com paredto m onths non-fam ilysetting)am ong fem alesonly:O R 3. PeerE ncouragem enttowardssex work:seven (2012) Range:18-26 respondentsm entionedpeerencouragem ent 16% F em ale towardssex work 12% W hite D ecision when to use 1. Socialnorm s:Repudiation of specific beliefs condom s aboutunsafesex com m on am ong peers Tyler& 4 M idwestern 40 M ean age:, Sex Trade 1. D iscussedpeersrelationships:Pressureto J ohnson states Range:19-21 engagein prostitution (2006) 60% F em ale % W hite Tyler,K. Socialnetwork norm s:3 youth saidthatthey & M elander, cities Range:16-21 behaviors havenorm swithin theirnetworksregarding safesex L. Atleastonestreetbasedcondom using peer Range:16-26 lastsex ualencounter connectedthrough interpersonalties:O R 0. For these reasons, we conducted exploratory eventlevel interviews which examine characteristics of the environment surrounding sexual events. Data comes from 47 in-depth descriptions of sexual episodes by 29 homeless youth who were asked to describe two recent sexual encounters. Youth were recruited from five community youth shelters and drop-in centers in the Hollywood and Westside regions of Los Angeles. Methods: Using grounded theory methods, we conducted across-events and withinevents analyses. Results: In thematic analyses of data across events, we found that whether sex was expected and use of alternative methods of protection against pregnancy were eventbased circumstances that respondents described as influencing engagement in condomless sex. We also identified factors that were not related to event circumstances yet influenced decision-making about using condoms. In addition, individual perceptions of diseases, concerns over pregnancy and discomfort using condoms were respondent characteristics that shaped homeless youths’ willingness to practice safe sex. Next, we conducted analyses of events within the same individuals and found that homeless youth identified multiple interacting influences on their condom use decision-making, with different pathways operating for event, partnership and individual levels. Conclusion: Future interventions targeting homeless youths’ condom use behaviors will benefit from taking a multilevel and personalized approach that addresses unique factors resulting in unprotected sex for each homeless youth. Both research and policy should pay particular attention to the partnership and context based determinants of unprotected sex in this population. Homeless youth become exposed to negative sexual health consequences due to risky sexual practices such as having multiple and/or high-risk partners (Johnson, Aschkenasy et al. In addition, homeless youth are likely to engage in sex trade as one study of homeless youth in the Mid-Western United States found that nearly one-third of the study sample had some exposure to trading sex, either having traded sex themselves or knowing someone in their social network that traded sex for resources (Tyler and Johnson 2006). The sexual health of these youth should be of immediate concern to policymakers as youth homelessness in on the rise (Moskowitz 2013) and, healthrelated challenges will impact the ability of youth to escape the web of homelessness. In this study, we focus on homeless youths’ decision-making about the use of male latex condoms. Yet, in a recent study among homeless youth in Los Angeles, only 40% of sexually active youth reported using condoms during their last intercourse (Tucker, Ryan et al. Consequently, it is not surprising that pregnancy rates in this age group are extremely high (Halcon and Lifson 2004). A study among female homeless youth in Los Angeles found that nearly 28% of the study sample had been pregnant or tried to become pregnant in the past three months (Tucker, Sussell et al. Efforts to encourage condom use among homeless youth require interventions to understand the social environments in which their sexual events take place. Ecological models of health state that an individual’s behavior can be impacted by multiple levels of influences—individual, social, cultural and contextual (McLeroy, Bibeau et al. Individual-level determinants such as knowledge, perceptions and self-efficacy regarding condoms may determine whether youth choose to use condoms in any given sexual event. For instance, some youth might choose to always carry condoms so that they can avoid any chance event of unprotected sex. These preferences may in turn take a backseat against the dynamics of the relationships that youth have with their sexual partners such as partner preferences for condom use, partner characteristics and if there are rules governing safety and pregnancy in the relationship. In some circumstances, despite having individual and relationship based preferences and rules about using condoms, some youth might have unprotected sex due to event specific characteristics such as the sexual event occurs unexpectedly and so condoms are unavailable or there was 40 consumption of alcohol due to which participants forget to use condoms. Consequently, homeless youths’ decisions and ability to use condoms may be determined by multiple environments with some of these factors being more proximal to the event while others operating in the background. However, none of the interventions being offered to homeless youth simultaneously address the multiple layers of influence. We believe that interventions have not taken a multi-layered perspective since few studies have explored the multiple levels of influences that homeless youth might experience when using condoms. To date only one study about condom use among homeless youth has used a multi-stage and multi-method design (Kennedy, Tucker et al. In fact, past literature has focused mostly on individual-level determinants of condom use in this population. Individual characteristics such as history of abuse, lack of motivation to use condoms, ambivalent views about pregnancy and, poor decision-making skills have been associated with increased likelihood of unprotected sex (Bailey, Camlin et al. Few studies that have focused on social network and contextual determinants of risky sexual practices among homeless youth have explored mostly the role of peer norms (Rice, Milburn et al. Consequently, a recent review concluded that the unique social context in which homeless youth live is increasingly impacting their ability to practice safe sex behaviors, yet very little is known about the context of homeless youths’ sexual events (Marshall 2008). We are not aware of any qualitative study that provides information about the contextual characteristics surrounding homeless youths’ sexual events and explores the multiple levels of influence that may predict decision-making about condom use in this population. Another weakness is that numerous studies have examined the determinants of condom use among homeless youth, but most of this work has focused on global associations or factors that influence an individual’s overall use of condoms. Global studies that summarize different level factors with quantitative assessments at the individual level are beneficial in that they allow us to test hypotheses and measure the impact of variables of interest with higher reliability such that results are comparatively generalizable. However, they don’t allow for the exploration or identification of mechanisms in cases where we don’t know enough about how predictors impact the main variable of interest as well as help establish the temporal pairing among variables which is an important condition for understanding casual relationships. For instance, a survey item that asks, “Do you often drink before or during having sexfi For instance, the association between substance and condom use could be confounded by the interplay of partner choice, reason for engaging in sex and amount of substance consumed among others.

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A used to arthritis relief gifts order genuine trental characterize the bioelectrical properties of particular focus will be communication targeted to arthritis in dogs products trusted trental 400 mg cardiac muscle what does arthritis in the knee look like buy trental 400mg fast delivery. The primary objective of this course is to best shoes for arthritic feet buy trental 400 mg cheap introduce Quantummechanical Basis of Nuclear Magnetic biomedical engineering students to the challenges Resonance. In order to achieve this goal, other objectives include: gaining a basic appreciation of Prerequisites: Basic physics and mathematics. Permission of instructor is ing, object recognition are challenging problems in required. Topics include scaling laws, colloids and surfaces, micro and nanofuidics, thermal forcMedical Imaging Systems. An introduction to the physics, instrumentation, and Computational Functional Genomics (580. It includes technology, which allows the simultaneous mearecent advances in various biomedical imaging surement of gene expression levels of thousand of modalities, multi-modality imaging and molecular genes. This course examines linear, discreteand continuoustime, and multi-input-output systems in control this course consists of weekly discussions of curand related areas. Topics covered ed readings will focus on neural mechanisms for include state-space models, stability, controllability, perception, attention, motor behavior, learning, and observability, transfer function matrices, realization memory, as studied using physiological, psychotheory, feedback compensators, state feedback, physical, computational, and imaging techniques. Models of single and multiple neural spike Physiological mechanisms of hearing and balance. Both thedischarge patterns, anatomy of the central auditory oretical methods and the properties of specifc well and vestibular systems, and synaptic transmission studied neural systems will be discussed. This course introduces tools from robotics, control Structure and Function of the Auditory and Vestheory, and computational neuroscience to undertibular Brain. Our focus is on how various parts of the cortical and Brain mechanisms and perception of sound and sub-cortical motor system contribute to the control balance. This course is an accompaniment for and learning of movements, and how motor disor580. Topics include representation of sound and balance in neural discharge patterns, 210. Includes exercises with stochased readings will focus on neural mechanisms for tic simulation of theoretical concepts. Students in this of stem cells and their applications to tissue engicourse will formulate mathematical models of signeering. Clinical and regulatory perspectives will be naling pathways and analyze their behavior using discussed. Contemporary Topics in the Engineering of Introduction to Nonlinear Dynamics in PhysiCells. Cardiac ionic currents, molecular correlates and blockers, calcium clock repolarization reserve, Prerequisites: Knowledge of signals and systems or alternans, electrical remodeling, cardiac memory, instructor’s consent. Topics covered will include: fractals; strange Models of Physiological Processes in the Neuattractors; bifurcations; state-space attractor ron. Single-neuron modeling, emphasizing the use of computational models as links between the propIntroduction to Orthopaedic Biomechanics. After an introduction, topics covered will include equilibrium theory Prerequisite: 580. Recommended: Matlab tions in complex environments, stochastic models, this course focuses on principles and applications dynamics of membrane and channels, theory of in cell engineering. Class lectures include an overbiological motors, computer simulation of liquids view of molecular biology fundamentals, experiand proteins. Lectures will cover the effects the course discusses the principles of biosensing of physical. Furthermore, topics in metabolic measurements of biological phenomena, and cliniengineering, enzyme evolution, polymeric biomatecal applications. Weekly threeintroduction to the physical principles, hardware hour lab session will be used to interact with the design, and signal processing used in magnetic instructors, and to implement and study computaresonance imaging Biomedical Engineering and tional models. The course is taught by a team of Computational Biology and Bioinformatics is not a experts in the respective felds and will provide an prerequisite for this course. State-of-the-art methods in dynamic vision, with an emphasis on segmentation, reconstruction, Systems Biology of Cell Regulation. Examples of the modeling and experimental textures, face and hand gestures, human gaits, studies of metabolic, genetic, signal transduction, crowd motion analysis), as well as geometric and and cell cycle regulation networks will be studied in statistical methods for clustering and unsupervised detail. The classes will alternate between considerlearning, such as K-means, Expectation Maximizaation of network-driven and network element (gene, tion, and Generalized Principal Component Analymetabolite or protein)-driven approaches. Our aim is to frst derive some of the important mathematical the cardiac myocyte is one of the most extensively results in learning theory, and then apply the framestudied cells in biology. As such, it serves as an work to problems in biology, particularly animal important example of how to develop quantitative, learning and control of action. 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The papers are presented by students, and this course uses the current literature to teach the audience typically includes a number of clinical advanced topics in cardiac electrophysiology and and basic science faculty, as well as graduate stumechanics. Evaluation will be both engineering principles to develop systems for by faculty and fellow students. Examples of research in this area include design Pattern Theory: From Representation to Inferof instrumentation for brain monitoring, developence. The nologies to probe from neurons and brain, and course begins with the study of Markov processes development and application of neural stimulators, on directed acyclic graphs, including Markov chains prosthesis, and deep brain stimulations and robotand branching processes, and on random felds ic/image-guided therapeutic devices. Numerous examples are examined in will then engage in a short project of clinical (or sciimage understanding and image analysis. Advanced Seminars in Integrative and Systems this course uses the current literature to teach Biology. Students will be required to read current papers, the course is designed to introduce the current selected textbook chapters and online content to concepts, methods and modes of analysis being prepare for interactive teaching sessions with faculdeveloped in the context of experimental and ty and other students. This course is designed for graduate students Students will be required to read current journal interested in learning basic biomedical instrumenarticles, online presentations and actively particitation design concepts and translating these into pate in the in-class discussions. Every student will advanced projects based on their research on curalso be required to be engaged in individual projrent state-of-the-art. They will systematically learn resonance imaging, radionuclide imaging, and optito design instrumentation with a focus on the use cal imaging techniques. Furimaging of neurodegenerative disease, and imagther, they will be “challenged” to come up with ing of cardiovascular disease. The emphasis of the some novel design ideas and implement them in overall course is to learn how molecular/cellular a semester-long design project. Students will take imaging will change the way future diagnostic radipart in reading the literature, learning about the ology and drug development will be practiced. The student will participate in “Journal Biophysics and Biophysical Chemistry Club,” in which important papers in the front-line biomedical literature will be discussed. Enrollment of non-medical students requires and Biophysical Chemistry, Professor of approval from the course director. At least one upper-level course in BioChemistry, Investigator of the Howard Hughes chemistry or Cell Biology is strongly recommended. Associate Professor of Cell Biology, Associate Elective courses must be approved by the Professor of Biophysics and Biophysical preceptor; any member of the department can Chemistry act as preceptor. Live-cell, single molecule studies of mechanisms of bacterial gene regulation and 100. Departments of Biological Chemistry and MolecuPrerequisites: Calculus, elementary physics, and lar Biology and Genetics. Recent topics have included: assigned readings from primary scientifc literature protein folding, evolutionary signifcance of introns, with computer-based lab assignments. Lectures will offer an introduction to the mathematithe structure and properties of biological macrocal aspects of computer representation and manipmolecules will be presented. Experimental and ulation of macromolecules followed by discussions computational methods used to study macromoof important topics in the computational chemistry lecular structure including X-ray crystallography, of macromolecules including: forces and potential magnetic resonance, spectroscopy, microscopy, felds, molecular mechanics, electrostatics, Monte and mass spectrometry will also be covered. Three the physical and chemical principles underlying hours per week; second semester; limited enrollment.

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