Resultant effects of mitochondrial oxidative stress and therapeutic potential of H2S in neurodegenerative diseases prostate cancer 2016 buy proscar 5 mg on-line. H2S also exerts its antioxidant function by binding drug molecule and activating protein precursors prostate oncology order generic proscar online. Although H2S neutralizes harmful hippocampus of lipopolysaccharide-treated rats in a oxidative modification in neurodegenerative diseases prostate cancer 9 score order generic proscar on-line, dose-dependent manner  prostate cancer 7 gleason score order proscar online pills. A major pathway by additional in vivo studies are needed to elucidate which H2S protects against cellular damage is the molecular mechanisms in oxidative stress. Pharmacological effects of H2S drugs in cell signaling has been assessed by in vitro the pharmacological effects of H2S are exerted studies. Studies of H2S-releasing drug in vivo are more by inhibition of H2S/H2S donors or augmentation of difficult than in vitro studies due to physiological and endogenous H2S; many experimental models have pathological conditions. To determine more fully the demonstrated the protective effects of H2S or potential pharmacological effects of H2S-releasing drugs, targets of H2S donors in neuromodulation, further research is necessary. For instance, sulfide salts Neurons have the capacity for cell–cell comprise donors of H2S that may have communication. Agent-based modeling of mitochondria links sub-cellular dynamics to cellular homeostasis and heterogeneity. This work was supported by Basic Science 2005;7(11-12):1664-1673 Research Program through the National Research 24. Competing Interests Protective Effect of Melatonin against Oxidative Stress-Induced Apoptosis and Enhanced Autophagy in Human Retinal Pigment Epithelium Cells. Oxidative Stress, Mitochondrial Abnormalities and Proteins Deposition: Multitarget Approaches in Alzheimer’s Disease. Abnormalities of Mitochondrial Imbalance as a Diagnostic Marker of “Free Radical Diseases. Imaging of superoxide and mitogen-activated protein kinase signaling in neurodegenerative diseases generation in the dopaminergic area of the brain in Parkinson’s disease, using with special focus on prion diseases. Hydrogen sulfide as a function, preserves medium spiny neuronal identity, and reduces oxidative regulator of calcium channels. Cystathionine synthase, a key enzyme for homocysteine metabolism, is World allergy Organization Journal. Curr Opin Cell lanthionine and homolanthionine and is responsive to the grade of Biol. Biochem by cystathionine lyase at the steady-state low intracellular Ca2+ Biophys Res Commun. Effect of hydrogen peroxide on the iron-containing treating, and predicting barbering: A fundamental role for biomarkers of superoxide dismutase of Escherichia coli. Low-voltage-activated (T-type) calcium-channel genes S-propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuated identified. Gas Signaling Molecules and Worthwhile Tool in the Design of New Multitarget Drugs. Hydrogen sulfide slows down progression of experimental Alzheimer’s disease by targeting multiple pathophysiological mechanisms. Mechanisms of hydrogen sulfide against the progression of severe Alzheimer’s disease in transgenic mice at different ages. Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death. A systematic review and integrative approach to decode the common molecular link between levodopa response and Parkinson’s disease. Elevated homocysteine by levodopa is detrimental to neurogenesis in parkinsonian model. Deficient Rab11 activity underlies glucose hypometabolism in primary neurons of Huntington’s disease mice. Cystathionine lyase deficiency mediates neurodegeneration in Huntington’s disease. Identification of lanthionine synthase C-like protein-1 as a prominent glutathione binding protein expressed in the mammalian central nervous system. A review of hydrogen sulfide synthesis, metabolism and measurement: Is modulation of hydrogen sulfide a novel therapeutic for cancer Comparison of adaptive neuroprotective mechanisms of sulforaphane and its interconversion product erucin in in vitro and in vivo models of Parkinson’s disease. Sulforaphane as a potential protective phytochemical against neurodegenerative diseases. Organ-specific exposure and response to sulforaphane, a key chemopreventive ingredient in broccoli: implications for cancer prevention. A change in metabolism has been implicated in the mechanisms of several age-associated diseases such as In yeast, both pathways play redundant yet essential roles diabetes, cancers and neurodegenerative diseases. This transcriptional feedback system, whose activ ity uctuates as a function of the light–dark cycle, controls the circadian rhythms in many organisms. The silencing status of these loci is thus considered as a read out of the Sir2p activity. Ageing in higher eukaryotes is a much more complex Furthermore, a point mutation in the mitochondrial gene process. This study future, therefore, it would be very interesting to Current Opinion in Cell Biology 2003, 15:241–246 Acknowledgements We thank Dean P Jones at Emory University for suggestions; and M Haigis, 16. Panozzo C, Nawara M, Suski C, Kucharczyka R, Skoneczny M, F Picard and M Viswanathan for critical reading of the manuscript. Papers of particular interest, published within the annual period of Mol Microbiol 2001, 40:1241-1248. Ramasamy R, Trueblood N, Schaefer S: Metabolic effects of life span by shifting carbon toward respiration. Brownlee M: Biochemistry and molecular cell biology of facultative bacteria and the effect of oxygen. The purpose of this Handbook is to explain scientific research and knowledge about McArdle disease in layman’s language so that it can be understood by people with McArdle disease or those interested in McArdle disease. It is not intended to replace medical advice from your family doctor or specialist. The information provided in this Handbook is correct to the best of the author’s knowledge. If you have any doubts about the accuracy of the information in this Handbook, it is recommended that you read the original source (full details in the reference list). Where no definitive information is available, the author has sought to suggest scientific rationale behind anecdotal observations reported by people with McArdle’s. Due to the nature of scientific research, current theories and understanding of the science behind McArdle’s may change over time and subsequently be proven or disproven. I would like to thank Mum, Dad and Madelyn for their continued interest and encouragement and for proof-reading the Handbook. Definitions of terms used in this Handbook In this Handbook, “McArdle person” is used to mean a person who has received a definitive diagnosis of McArdle disease (who has no functional muscle glycogen phosphorylase enzyme in their 1 skeletal muscle cells). There is also a glossary at the end of the Handbook for scientific or medical words used frequently in the Handbook which would not be included in a standard English glossary. Anaerobic exercise is a short burst of high intensity effort, such as a sprint for a bus. However, only a small amount of glucose is present in the muscle cells and this is used up within a few minutes of anaerobic exercise. In people unaffected by McArdle disease, the process of converting glycogen into glucose requires several enzymes, one of which is called “muscle glycogen phosphorylase”. McArdle disease is caused by the lack of the muscle glycogen phosphorylase enzyme in muscle cells. In McArdle people, muscle glycogen phosphorylase is either absent or not functional. The short term lack of glucose causes tiredness and stiffness in muscles of McArdle people when they carry out anaerobic exercise (Rommel et al. A period of rest is necessary because these other methods are slower to produce energy than glycogenolysis (the method which normally involves muscle glycogen phosphorylase). This can lead to breakdown of muscle cells (rhabdomyolysis) and muscle cramps (contractures), both of which cause McArdle people to experience muscle pain. Following rhabdomyolysis, the components of the broken muscle cells are released into the bloodstream.
However prostate cancer 2c cheap proscar uk, when the production of communicative acts is considered in relation to man health world buy proscar 5mg fast delivery the sample’s duration the data about both groups are different prostate oncology specialists inc order cheap proscar, suggesting that the reciprocity between mother and child forms the base from which communication develops man health policy buy proscar master card. In the first aspect, communicative space occupation, the mother seems to be the agent of the balance. The difficulties presented by autistic children with the interactive use of communication reinforces the notion that isolated and specific social and cognitive elements evolve together with the linguistic and non-linguistic communication development and there is a mutual interference in the process. The option of conducting the data gathering in communicative situations with the mothers provided a familiar interlocutor that probably allowed each child’s best performance. The characterization of the functional communicative profile confirmed the areas of larger difficulties. The presence of large individual differences demands other studies comparing more homogeneous groups. The interactive situation is a privileged one because each child has his/her own mother as a communicative partner. Knowing the child’s communicative needs the mother works as a facilitator to the communication and places the child as the central focus of her attention (at 10 A Comprehensive Book on Autism Spectrum Disorders least during the data gathering period). Prior studies (Chawarska et al, 2007; Clifforf & Dissanayake, 2008; Davis & Crter, 2008; Ruser et al, 2007; Scheeren & Stauder, 2008; Solomon et al, 2008) point out to the mother’s important role as a communicative partner to the communication development process and eventually in the assessment processes. The mother represents a preferred partner to the child, determining an affective association that will generate symmetric communication patterns (Wachtel & Carter, 2008; Williams et al, 2005). Mothers use simple, repetitive speech, grammatically and semantically adjusted to the child’s understanding and interest levels (Grindle et al, 2009). In this sense, the largest data dispersion referring to the non-verbal children with more than 3 years of age shows how difficult is this process undertaken by the mother, of building a symmetric communication and therefore of building her own role as a communicative partner. Another research (Benson et al, 2008) studied the communication of autistic children in different contexts and observed variations in the use of the different communicative means according to the communicative partner. According to the authors when the interlocutor is less efficient (in the case of this study, a group situation without an adult’s facilitation) the use of redundant communicative means is necessary, and so the gestural means may support what is conveyed by the verbal mean, for example. The analysis of the use of the interpersonal communicative functions provides data about the child’s interactive competence and the data presented show the autistic children’s impairment in this domain. This observation confirms prior studies (Grindle et al, 2009) that concluded that autistic children are less responsive to interactive attempts and have less spontaneous communication. Other studies (Bara et al, 2001; Davis & Carter, 2008; Laugeson et al, 2009; Reed et al, 2007) report the severe impairment of autistic children in the interactive use of communication to specific functions. This way of measuring, controlling and standardizing variables of spontaneous production from the therapeutic context to different situations is essential to provide objective data for language assessment and intervention with autistic children. Therefore, the aim of this study was to determine the communicative performance of individuals of the autistic spectrum in non-familiar situations (with unknown material and communication partner) for a period of 15 minutes of interaction in free-play situations (Moreira & Fernandes, 2010). There were no significant differences in what refer to the communicative means and to the interpersonal communicative functions. Just two non-interpersonal communicative Language Assessment in Autism 11 functions (Play and Non-Functional) were expressed with different frequencies during the different situations. The comparison between the two different situations has shown few differences between the familiar and the non-familiar situations. However, despite the small differences the familiar situation was the most effective since it has leaded to the occurrence of the largest number of communicative acts per minute and the greatest proportion of responses. The communicative situations were determined and the communicative contexts varied according to the individual or group activities proposed by the adult or chosen by the subjects. During a twelve-month period two recording sets were performed, initial and final, for each subject. Each recording set was carried out in three different situations, lasting 30 minutes each. In what refer to the communicative situations, it was possible to observe that the subjects presented similar communicative behaviors in the three of them. There was an increase in the number of communicative acts, differing only in relation to the average of occurrence, probably due to the dispute for the communicative space in group situations. The results demonstrated that the performance throughout the different situations studied during the 12-month period presented variations in all analyzed items. When the functional communicative profile was investigated, the variable number of communicative acts may be once more confirmed as an interesting focus of assessment (Cardoso & Fernandes, 2003; Fernandes, 2003). It was also observed an association between the functional communicative profile and the social-cognitive performance, showing a strict correlation between language and cognitive development (Anderson et al, 2007; Cardoso & Fernandes, 2006; Fernandes & Ribeiro, 2000). In all situations there were changes in either the functional communicative profile and in the social-cognitive aspects, being possible to verify the association between the participants’ performance in these two aspects. It is important to stress that the changes in the performance may be considered interconnected, however nonlinear. Another aspect that should be considered is that the subjects of this study were low functioning adolescents without previous therapy, and the assessment criteria and instruments were appropriate to this specific group. The use of objective measures to analyze spontaneous language samples Due to autistic children’s characteristics such as lack of social engagement, the use of spontaneous speech samples may provide important information about their functional linguistic performance especially when environmental variables such as familiarity and cognitive demand are controlled. The use of objective measures to analyze spontaneous communicative samples may lead to important and meaningful results. These communicative functions are divided in more interpersonal and less interpersonal. A communicative acts starts when the interaction is initiated and ends when there is a shift on the attention focus or on the communicative turn. The communicative functions considered (Fernandes, 2004) are 20 alternatives specifically described and that can be divided, according to Fernandes & Galinari (1999) as interactive (or interpersonal) and non-interactive (or less interpersonal): Interactive communicative functions: Object Request, Action Request, Social Routine Request, Consent Request, Information Request, Protest, Recognition of Other, Comment, Labeling, Expressive, Narrative, Joint Play, Protest Expression and Showing Of. This is not a simple or effortless task but its applicability in several and different contexts, without any specific material, is undoubtedly a great advantage. Obviously in situations where the subject produces very little oral language, the proportional number should be calculated. Another important aspect to be considered is the need of specific parameters for each language and eventually for different groups, once grammatical differences interfere enormously on the number of morphemes of each utterance, regardless of its meaning (Befi Lopes et al, 2007). Singing and delayed echolalia should be excluded from the analysis since they don t represent the individuals grammatical performance. The grammatical classes considered usually are: adverbs, adjectives, articles, conjunctions, prepositions, pronouns, nouns and verbs. There is a clear need for more studies about the best way to access vocabulary in this population as well as about language and group-specific parameters. Apparently the use of computer generated images facilitate the children’s participation but the answers on a controlled situation do not always express the performance in real communicative situations. Therefore, aspects such as social-cognitive performance, social-communicative adaptation and meta representation should be part of the procedure. The situation to determine the child’s best performance in seven domains can vary according to the examiner’s intentions and demands: Spontaneous situations: have the advantage of allowing repetitions as frequent as needed, but eventually to not include opportunities that demand the best performance. The child expresses emotional reactions to objects/events, including clapping, smiling, making a face and hitting. The child emits signs that are contiguous to the goal, to the child’s own body or to the adult’s body; the child reports to the adult. The child repeats the same gesture until the purpose is achieved; the child reports to the adult. The child modifies the gesture shape until the purpose is achieved, that is, the child repeats the gesture with an extra element; the child reports to the adult. The child emits ritualized gestures that are not contiguous to the goal, to the child’s body or to the adult’s body, that is, the same gesture must be used in at least two occasions in the same communicative context to be qualified as a ritual; the child reports to the adult. The child vocalizes while he/she manipulates or examines an object or while ignores an object and does not report to the adult. The child expresses emotional reactions to objects/events, including screams, laughs, crying. The child emits vocal signs referring to an object or to the adult; the same sing must be used in at least two different communicative contexts. The child repeats the same vocal sign until the purpose is achieved; the child reports to the adult. The child modifies the vocal sign until the purpose is achieved, that is, the child repeats the gesture with an extra element; the child reports to the adult. The child emits ritualized sounds, that is, the same sign must be used in at least two occasions in the same communicative context to be qualified as a ritual; the child reports to the adult.
The person in this role communicates with the parents about early development and specific symp parents and referring professionals before the evalua toms of autism as well as observing the child directly tion to mens health quizzes discount proscar amex understand the referral questions prostate cancer juice cure purchase discount proscar on-line, organizes ap (Filipek et al prostate infection symptoms order proscar canada. In the relatively short obser viders in the community who will implement the rec vation of the child done in most clinic settings prostate cancer fatigue buy generic proscar 5mg, the full ommendations from the evaluation, and perhaps moni range of difficulties experienced by the child will tors later treatment. This type of coordination is critical likely not be evident, so parent report is vital. The specific ap gained from these sources can then be integrated into a proach will depend on the goal of the assessment. The publication of two standardized assessment low at age 2, but good by 3 years. Use of these and other the Social Communication Questionnaire (for tools described in this article has advanced scientific merly known as the Autism Screening Questionnaire; progress and improved the accuracy and reliability of Berument, Rutter, Lord, Pickles, & Bailey, 1999; Rut diagnostic assessment (Filipek et al. It is administered by a trained clinician 2002), and it is thus an efficient way to obtain diagnos using a semistructured interview format. The lifetime version is which includes only the items on the diagnostic algo helpful for screening and diagnostic purposes, whereas rithm, maybeusedforclinicalassessmentandtakesless the current version is more appropriate for assessment time, approximately 90 min (Lord et al. Using these also available; it is helpful but not required for routine cutoffs, sensitivity of. Several studies have demon enough to provide an adequate range of behavior but strated that the rate of both false positives and false young enough to precede major changes that may oc negatives produced by the Autism Behavior Checklist cur with age (Lord et al. The items that empiri is quite high and that most higher functioning children cally distinguish children with autism from those with are not identified by the cutoff of 67 (Sevin, Matson, other developmental delays are summed into three al Coe, Fee, & Sevin, 1991; Sponheim & Spurkland, gorithm scores measuring social difficulties, commu 1996; Volkmar et al. It is ter, Noterdaeme, & Amorosa, 2001) and general devel typically completed by parents and is appropriate to opmental delays (Cox et al. Ratings are made on a 4-point ences, when present, are most distinct in early child scale, summed, and converted to standard scores based hood (Ozonoff, South, & Miller, 2000), and the two on the reference sample (but not broken down by age or conditions appear to converge phenomenologically at gender). The primary score of interest is the Autism older ages (Howlin, 2003; Starr, Szatmari, Bryson, & Quotient, which is intended to measure “the likelihood Zwaigenbaum, 2003). Reference sarily been incorporated into clinical practice, how data come from more than 1, 000 North American chil ever, and there remains a conviction among clinicians dren with informant-reported (but not verified) diagno that the two are distinct conditions. The Autism Spectrum Screening Questionnaire However, there is only one empirical report of the (Ehlers, Gillberg, & Wing, 1999) is a 29-item check psychometric properties of the Gilliam Autism Rating list standardized for completion by lay informants. The Autism Spectrum than half were rated as having below average or very Screening Questionnaire has high internal consistency low likelihood of autism by the Gilliam Autism Rating and good validity (Ehlers & Gillberg, 1993). There are no published the Parent Interview for Autism (Stone, Coonrod, psychometric studies of the Gilliam Asperger’s Disor Pozdol, & Turner, 2003) is a new instrument developed der Scale, but it is widely used in some settings, such as specifically for the purpose of measuring change in au schools. It is appropriate for (Myles, Bock, & Simpson, 2001) is appropriate for preschool children ages 2 to 6. There are sistency and can differentiate autism from nonautistic no published studies of its psychometric qualities. The questionnaire covers both autistic toms that are not part of the diagnostic criteria and are symptoms and adaptive and maladaptive behaviors that controversial aspects of the phenotype. These measures may have some utility for degree of internal consistency, provides adequate broadly identifying any high-functioning autism spec test–retest reliability (Cohen et al. These measures high-functioning autism, as well as the practical con may prove useful for practitioners wishing to track the cerns raised by differential insurance reimbursement progress of patients enrolled in treatment programs. One cannot always be test–retest reliability, and criterion-related validity sure that a behavior is deficient after only an hour of (DiLalla & Rogers, 1994; Eaves & Milner, 1993; Sevin observation, but this is often all the time a professional et al. Once several chances to display retardation as having autism (Lord, 1997; Saemundsen these typical social behaviors are missed, a clinician et al. It was developed as a tool to rate behavior can be reasonably certain that the behavior in question observed during developmental evaluation but has also is difficult for the child being assessed. The Childhood Autism Rating symptoms, as there are no presses for repetitive and Scale is a frequently used measure (Luiselli et al. Several measures are available for sess social interest, joint attention, communicative be collecting information from parents and direct obser haviors, symbolic play, and atypical behaviors. In many thy, insight into social relationships, and special inter cases, practical constraints will dictate choices. There time, training requirements, and applicable age ranges are shorter clinical trainings for clinicians not involved to assist examiners in choosing among them. Diagnostic validity (sensitivity and specificity) for observation or structured interaction with a practitio autism versus nonspectrum disorders was also excel ner. On occasion, these measures widely used in empirical studies of autism and has provide discordant information (de Bildt et al. Items are scored on a 7-point Intellectual Assessment scale (from typical to severely deviant) and summed into a composite score that ranges from 0 to 60. Scores A second important domain that must be part of the above 30 are consistent with a diagnosis of autism, al assessment is intellectual functioning. Intellectual as though lower cutoffs have been recommended for ado sessment helps frame the interpretation of many obser lescents (Garfin, McCallon, & Cox, 1988). When Handleman, 2000; Lotter, 1974; Rutter, 1984; Stevens experienced clinicians evaluate children with autism, et al. Scores can and do change with development and direction) of standard scores, and (c) measures verbal intervention (Freeman et al. The Leiter International Performance Scales– use of language, frequent off-task behaviors, high Revised (Roid & Miller, 1997; Tsatsanis et al. Motivation can appropriate for individuals with a mental age of 2 years have a tremendous influence on test results, and assess or higher and requires no expressive or receptive lan ments that incorporate reinforcement procedures can guage skills. The Differential Abilities Scales (Elliott, result in very different test scores (Koegel, Koegel, & 1990) assess both intellectual and academic skills. It is important to enhance motivation as growing in popularity and use because it can be admin much as possible without altering the standard admin istered to children across a wide chronological and istration of the instrument and consider the motiva mental age range (2 through 17 years), making it tional element when interpreting scores. One benefit of the Mullen Scales of Early Learning is often chosen over Stanford–Binet is the very wide age range of individu the Bayley Scales due to its wider age range and five als for whom it is appropriate (2 to 85 years). The re distinct scales that allow separate assessment of verbal cently revised fifth edition (Roid, 2003) included 108 and nonverbal abilities. The Bayley Scales have a lon children with autism in the normative sample and add ger research tradition than the Mullen Scales of Early ed entry items, improving measurement of young chil Learning but yield less detailed information, with one dren, lower-functioning older children, and adults with score averaging memory, problem solving, communi mental retardation. These instruments provide nonverbal individuals, because half the subtests utilize both standard scores and developmental age equiva a nonverbal mode of testing. Thus, they can be used to evaluate children who Stanford–Binet may be a good choice when examiners are older than the test norms but whose developmental must select an instrument before knowing a child’s skills are not high enough to administer more age-ap abilities or when longitudinal assessment is planned. For children with spoken language, the Wechsler In telligence Scales are the most widely used intellectual Language Assessment instruments. They with adequate spoken language, who score in the aver also, as a group, demonstrate larger head circumference age range on these tests, may still exhibit deficits in the and brain volume than children without major nonver use of language in a social context. Pragmatic commu bal–verbal discrepancies (Tager-Flusberg, & Joseph, nication includes nonverbal behaviors. Measuring adaptive behav ficient higher order conceptual processes, such as ab ior is also important for setting appropriate goals in stract reasoning (Minshew, Goldstein, & Siegel, 1997). Adaptive abilities largely deter They often perform acceptably on simple language, mine whether an individual requires constant supervi memory, and perspective-taking tasks but show defi sion or is capable of some independence. Data from an important measure of outcome that has been used in neuropsychological testing may be able to provide many longitudinal and treatment studies. However, neuropsycholog autism consistently demonstrate adaptive behavior lev ical testing is costly and time consuming, and its use els that are lower than their intelligence, and this pat may be impacted by managed-care concerns (Piotrow tern is most pronounced for higher functioning and ski, 1999). The domains of functioning include Klin & Shepard, 1994; Ozonoff, Dawson, & McPart communication, daily living skills, socialization, and, land, 2002). The Vineland is view of all domains of neuropsychology; in the follow completed during an interview with a parent or teacher ing we discuss three areas of particular interest with and is appropriate for children up to age 19 and men this population. Neuropsychological assessment is not tally retarded adults (separate norms are provided for usually useful (or even possible) with nonverbal or each population). A re ranted for higher functioning individuals when there cent study found that the Vineland was moderately are unexplained discrepancies or weaknesses in school performance, behavioral difficulties that appear to sensitive to changes due to developmental progress stem from undiagnosed learning disorders, and sus (Charman, Howlin, Berry, & Prince, 2004). They do, however, have ents, rather than interviews, and require little to no difficulty with focused attention. Depending on the referral question(s), goals of the For these children, a traditional attention deficit hyper assessment, and practical constraints such as finances, activity disorder work-up is indicated (see Pelham, insurance reimbursements, and waiting lists, a more 2005). The executive function domain 5 to 18 years that has 86 questions and takes about 10 includes the many skills required to prepare for and ex min to complete. Clinical scales measure inhibition, ecute complex behavior, such as planning, inhibition, cognitive flexibility, organization, planning, metacog organization, self-monitoring, cognitive flexibility, nition, emotional control, and initiation. Because executive functions are im tap everyday behaviors indicative of executive dys portant to school success (Clark, Prior, & Kinsella, function that may not be captured by performance 2002), predict response to treatment (Berger, Aerts, measures, such as organization of the school locker or van Spaendonck, Cools, & Teunisse, 2003) and long home closet, monitoring of homework for mistakes, or term outcome (Szatmari, Bartolucci, Bremner, Bond, trouble initiating leisure activities.
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